lipoic acid

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li·po·ic ac·id

(li-pō'ik as'id),
A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (-S-S-) form in the transfer of "active aldehyde" (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (that is, dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes.

lipoic acid

(lĭ-pō′ĭk)
n.
An organic acid, C8H14S2O2, that is essential for decarboxylation of pyruvate to acetyl coenzyme A during aerobic metabolism. It is also used as a dietary supplement for its antioxidant properties.
References in periodicals archive ?
These supplements provide 100% R-lipoic acid, which can be readily utilized by the body, maximizing its potential health benefits.
R-lipoic acid and vitamin C decline in cells with aging and oral supplementation with R-lipoic acid in old rats improved mitochondrial function, decreased oxidative damage, and reversed the age-associated effects on vitamin C concentration.
Studies indicate R-lipoic acid inhibits cross-linking--the chemical formation of bridges between body proteins or other large molecules believed to contribute to aging through such processes as hardening of the arteries, reduction of skin elasticity that cause wrinkles and the stiffening of joints.
Studies show that giving older animals R-lipoic acid leads to improved metabolic function, healthier mitochondria, and reduced production of oxidative stress-inducing byproducts.
Due to the individual's family history of Alzheimer's disease, preventive approaches with nutrients like acetyl-L-carnitine, vitamin D, CoQ10, N-acetyl cysteine (NAC), curcumin, and R-lipoic acid could be suggested.
(14) Lipoic acid is well tolerated and effective for prolonged use at 600 mg per day (equivalent to 300 mg of R-lipoic acid)--a level that noticeably improves muscle function and stops further impairment in movement.
Lynne Shinto and colleagues randomized 39 participants with Alzheimer's disease to receive a daily regimen consisting of fish oil concentrate, fish oil plus R-lipoic acid, or a placebo for one year.
Nutrient Typical Daily Dose CoQ10 as ubiquinol 100-200 mg Pyrroloquinoline quinone (PQQ) 10 mg Acetyl-L-carnitine arginate 675 mg R-lipoic acid 150 mg Aging Factor 5: Hormone Imbalance
An important animal study has now demonstrated that supplementation with R-lipoic acid reverses age-related accumulation of iron in rat brain tissue and restores normal antioxidant activity.
(59) This translates into a 300 mg dose of R-lipoic acid to obtain the same biological activity.
(124) Lipoic acid exists in two mirror-image forms: R-lipoic acid and S-lipoic acid.
* A dramatic new study has unveiled an advanced new formulation of lipoic acid called sodium-R-lipoic acid, which is more potent and stable than pure R-lipoic acid. Sodium-R-lipoic acid is the next-generation lipoic acid, which reaches higher plasma levels of lipoic acid sooner than pure R-lipoic acid.