capsaicin

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capsicum

 [kap´sĭ-kum]
a plant of the genus Capsicum, the hot peppers, or the dried fruit derived from certain of its species (cayenne or red pepper); it contains the active ingredient capsaicin and is used as a counterirritant and also in pepper spray.

cap·sa·i·cin

(kap-sā'i-sin),
Alkaloidal principle in the fruits of various species of Capsicum, with the same uses. It depletes substance P from sensory nerve endings; sometimes used for pain in postherpetic neuralgia.

capsaicin

/cap·sa·i·cin/ (kap-sa´ĭ-sin) an alkaloid irritating to the skin and mucous membranes, the active ingredient of capsicum; used as a topical counterirritant and analgesic.

capsaicin

(kăp-sā′ĭ-sĭn)
n.
A pungent alkaloid, C18H27NO3, derived from certain capsicums that is a strong irritant to skin and mucous membranes and is used in some topical pain relievers and in pepper sprays.

capsaicin

[kapsa′isin]
an alkaloid irritating to the skin and mucous membranes, the pungent active principle in capsicum. It is used in a cream that is a counterirritant and topical analgesic and also in pepper spray. See also capsicum.
Alternative nutrition A nutraceutical or food component from hot pepper that may prevent or mitigate disease and which may block pain signals
Source Chilli peppers
Neurology Capsaicine A chemical from hot chilli peppers that may be used in managing painful dysesthaesias of herpes and diabestes
Management Casein, a lipophilic phosphoprotein, acts like a detergent and strips the capsaicin from the receptors in the oral cavity

capsaicin

Neurology Capsaicine A chemical from red hot chili peppers that may be used for painful dysesthesias of herpes and DM; topical capsaicin triggers release of the neuropeptide, substance P from type C nociceptive fibers, opens Ca2+ and Na+ channels causing the initial pain associated with 'hot' foods; substance P is not replenished, thus pain sensation is ↓ after the initial pain; capsaicin binding is relatively strong and attributed to its lipophilic side chain Management Casein, a lipophyilic phosphoprotein acts like a detergent and strips the capsaicin from the receptors in the oral cavity; topical capsaicin may ↓ the symptoms of painful diabetic neuropathy. See Blister beetle, Scoville unit, Spicy foods.

cap·si·cum

(kap'si-kŭm)
Dried herbal remedy (and spice) made from Capsicum frutescens and other Capsicum spp.; both internal and external medicinal uses have been described (e.g., analgesic, therapy for GU problems).
Synonym(s): capsaicin, cayenne, hot pepper, red pepper.
[L., fr. capsa, box, case]

capsaicin

A pain-killing drug for external application used in the treatment of post-shingles pain and other painful peripheral nerve disorders. Brand names are Axsain and Zacin.

Capsaicin

An alkaloid found in hot peppers that is used in an inhalation test to identify patients with MCS.

capsaicin

chilli derivative; see rubefacients

capsaicin (kap·sīˑ··sin),

n a major ingredient in hot peppers; eaten to encourage sweating in hot climates and used as a topical pain reliever and to reduce nasal polyps. Capsaicin has also been used in melanoma treatment and may have chemoprotective qualities. Toxic effects may include nerve damage and carcinogenesis.

cap·sa·i·cin

(kap-sā'i-sin)
Alkaloid used for analgesia.
[Irreg. fr. capsicum, + -in]

capsaicin (kapsā´isin),

n brand names: Zostrix, Capzasin-P, Axsain;
drug class: topical analgesic for selected pain syndromes;
action: depletes and prevents reaccumulation of substance P in peripheral sensory neurons;
uses: neuralgia associated with herpes zoster, rheumatoid arthritis, temporomandibular joint (TMJ) pain.
References in periodicals archive ?
The high-dose capsaicin containing dermal patch Qutenza (Rx) was developed by NeurogesX and licensed to Astellas Pharma Europe in 2009.
The original EMA approval for Qutenza was obtained in 2009 for the treatment of peripheral neuropathic pain excluding diabetic polyneuropathy.
In the agreement, Acorda has paid approximately USD8m to acquire development and commercialisation rights for Qutenza and NP-1998 in the US, Canada, Latin America and certain other territories.
Astellas Pharma Europe Ltd has exclusive commercialisation rights for Qutenza in the European Economic Area (EEA) including the 27 countries of the European Union, Iceland, Norway, and Liechtenstein as well as Switzerland, certain countries in Eastern Europe, the Middle East and Africa.
Vimpat, Qutenza, Fentora are some of the pipeline candidates in the regulatory filing stage for approval.
the market is clearly coming to grips with the power of Qutenza.
We expect the company to secure a pan-European commercial partner for Qutenza in the next few months.
NeurogesX Inc's (NASDAQ: NGSX) Qutenza, a cutaneous (skin) patch designed to treat peripheral neuropathic pain conditions, has significant market opportunity, in our view.