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A class of alkaloids that are derived biosynthetically from anthranilic acid.
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A series of quinazoline derivatives (39-42) were evaluated for their biological activity as potential antitumor agents [34] (see Schemes 41 and 42).
Doxazosin, an quinazoline derivative a1 adrenoreceptor antagonist, has been known to exert antitumor effect via induction of apoptosis in PC-3 cancer cells [22].
For this significant antimalarial approach several nitrogen containing molecules were synthesized, docked and proved potent as like derivative of benzimidazole, quinazoline, piperizine and piperidine [41].
Quinazoline is a bicyclic compound having two nitrogen atoms, present in same ring in a 1,3 fashion.
An infusion made from the leaves of the drug was shown to exhibit expectorant and bronchial-dilating activities by virtue of the presence of the quinazoline alkaloid vasicine (Hansel, 1991).
These alkaloids include quinazoline, quinaxaline, cinnoline, phthalazine and other three or four membered ring azaheterocycles such as, pteridine, alloxazine, isoalloxazine [1].
Summary: A series of novel 6-substituted quinazoline derivatives were synthesised as epidermal growth factor receptor(EGFR) and Human epidermal growth factor receptor 2 (HER2)inhibitors in our lab.
Based on literature review, 10 ligands [A1-A5, NIT-D, compound-6 (with a quinazoline core), P02, Doxytetracycline (with tetracyclic ring structure) and Rolitetracycline (with tetracyclic ring structure)] were downloaded from Maybridge chemical database (48).
Sun Chemical has added pigments to our portfolio to support the efforts, including: Fanchon Orange 67, an opaque and brilliant pyrazolo quinazoline orange pigment for powder, solvent and waterborne coatings; Sunbrite Red 168, an anthanthrone mid shade red having the best lightfastness of red organic pigments, useful for coil, architectural, farm and implement and Sunbrite Red 177, an aminoanthraquinone, having exceptional heat and lightfastness that has been quickly adopted for critical applications requiring those attributes.
As a continuation of our interest in the reactions between methionine- and histidine-containing peptides and dinuclear Pt(II) complexes with six-membered aromatic diazines as bridging ligands, in the present study, we describe synthesis and characterization of three new dinuclear platinum(II) complexes, [[{Pt(en)Cl}.sub.2]([mu]-qx)][Cl.sub.2] x 2[H.sub.2]O (1), [[{Pt(en)Cl}.sub.2]([mu]-qz)][(Cl[O.sub.4]).sub.2] (2), and [[{Pt(en)Cl}.sub.2]([mu]-phtz)] [Cl.sub.2] x 4[H.sub.2]O (3) (qx = quinoxaline, qz = quinazoline, phtz = phthalazine, and en = ethylenediamine).
The main alkaloid components are derivatives of quinazoline and [beta]-carboline [10], which have exhibited anticancer and antibacterial activities in pharmacological studies [4, 10].