Quaternary Syphilis

par·a·syph·i·lis

(par'ă-sif'i-lis),

Any condition indirectly due to syphilis.

Synonym(s): metasyphilis (2) , parasyphilosis, quaternary syphilis

The fourth chronologic stage of syphilis, which may follow tertiary syphilis in immunocompromised patients, e.g., those with AIDS, and is characterised by necrotising, spirochete-laden encephalitis, variably accompanied by evidence of end-stage HIV-1-induced anergy and/or loss of cell-mediated immunity against treponemal antigens