Selection of resistant mutants with current STAT-C is not surprising as HCV bears all the characteristics required for the generation of mutant viruses, including rapid turnover (1012 virions a day) due to high replication levels and a quasispecies
distribution of viral populations.
Hepatitis C virus (HCV) circulate as a population of different but closely related genomes: quasispecies
nature of HCV genome distribution.
Further studies evaluating viral fitness of West Nile virus quasispecies
in terms of population-dependent host-virus interactions, are warranted.
analysis was performed on the specimens that shared identical NS5b sequences (3).
In addition, HCV has a high rate of spontaneous mutation, producing discrete "quasispecies
" that vary from one individual to the next (195).
Middle East respiratory syndrome coronavirus quasispecies
that include homologues of human isolates revealed through wholegenome analysis and virus cultured from dromedary camels in Saudi Arabia.
HCV core protein is a structural protein and its sequence is highly conserved among all HCV genotypes and quasispecies
. (9) Detection of HCV core antigens (HCVcAg) for the diagnosis of HCV infection, particularly in the pre-seroconversion window period (PSWP), can be accomplished by several assays that are available for research or commercial purposes, using serum, plasma or whole blood samples.
Rapid quantitation of neuraminidase inhibitor drug resistance in influenza virus quasispecies
. Antivir Ther 2008;13:809-20.
In chronic hepatitis, an acute increase in aminotransferases mimicking acute hepatic injury can occur with clearance of HBV e antigen (HBeAg) (45) or with emergence of quasispecies
of HCV (46).
No similar mutations occurred in parallel transmission chains leading up to patients 35, 168, and 163, suggesting that quasispecies
sampling during transmission events has been stochastic rather than selective.
Dynamics of virus quasispecies
during serial passages in heterologous hosts.
This inadequacy may be further strengthened by the nonrandom distribution of HCV quasispecies
in plasma and peripheral blood mononuclear cell subsets (9).