KAT6B

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KAT6B

A gene on chromosome 10q22.2 that encodes a histone acetyltransferase which, depending on the context, up- or downregulates transcription. KAT6B is required for RUNX2-dependent transcriptional activation and may be involved in development of the cerebral cortex. It is part of the MOZ/MORF complex, which has histone H3 acetyltransferase activity.

Molecular pathology
Defects in KAT6B are a cause of genitopatellar syndrome and Ohdo syndrome (SBBYS variant). Chromosomal defects  of KAT6B have been linked to acute myeloid leukaemias via translocation t(10;16)(q22;p13) with CREBBP.
References in periodicals archive ?
The QKF method is employed on all the CPs simultaneously, and the UAVs identify the current highest uncertainty to approach next (originally presented in [5]).
Compared to EKF [13], RMEKF [14], QKF [15], UKF [16], and PF [17], the main advantages of complementary filter are the simpler structure, the lower computational complexity, and the easier filter tuning.
We compare our algorithm with a novel quaternion Kalman filter (QKF for short) [15], which employs a special manipulation on measurement equation to eliminate usual linearization procedure, resulting in better performance than typical extended Kalman filter for quaternion estimation.