One group did not receive a second dose of 40 mg/kg PZQ
; therefore this was the single treatment arm, that is, only treated at baseline.
Schistosoma mansoni is the major etiological agent of human schistosomiasis, for which the treatment is dependent on a single drug, praziquantel (PZQ
Because of the extensive distribution of schistosomes and morbidity due to egg deposition, researchers have been interested in the influences of schistosome infections on concomitant diseases (Osada and Kanazawa, 2011).There is yet no vaccine available and thecurrent mainstay of control is chemotherapy with praziquantel (PZQ
All experiments were carried out in triplicate and repeated at least three times, using 10 [micro]M praziquantel (PZQ
) as positive control group, and RPMI 1640 medium and RPMI 1640 with 0.5% DMSO as negative control groups.
In previous studies, researchers have focused either to increase PZQ
concentrations in plasma by concomitant administration of cimetidine or food [9, 10] or to improve the dissolution rate using adjuvants such as cyclodextrins and polyvinylpyrrolidone [11, 12].
treatment did not significantly alter allergen-specific responses which would mediate pathology in allergic disease.
Providence Resources PLC (Providence) (PZQ
.DB), an Ireland-based oil and gas exploration and production company, has signed a strategic collaboration agreement with PGS Ventures A/S (PGS Ventures), a division of Petroleum Geo- Services.
Also scheduled are the modernisation and renovation of the three CHU hospitals (PZQ
, Clarac and Victor Fouche), as well as replacement of the majority of bio-medical and IT equipment.
At present, praziquantel (PZQ
) is the only drug recommended for the treatment and control of schistosomiasis, although it is not active against schistosomula and young worms and does not prevent reinfection (Sabah et al., 1986; Doenhoff et al., 2000).