pyruvate

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pyruvate

 [pi´roo-vāt]
a salt, ester, or anion of pyruvic acid. Pyruvate is the end product of glycolysis and may be metabolized to lactate or to acetyl CoA.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

py·ru·vate (Pyr),

(pī'rū-vāt),
A salt or ester of pyruvic acid.
Farlex Partner Medical Dictionary © Farlex 2012

pyruvate

(pī-ro͞o′vāt, pĭ-)
n.
A salt or an ester of pyruvic acid.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

py·ru·vate

(pī'rū-vāt)
A salt or ester of pyruvic acid.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Pyruvic acidclick for a larger image
Fig. 264 Pyruvic acid . Molecular structure.

pyruvic acid

or

pyruvate

an important 3-carbon molecule formed from GLUCOSE and GLYCEROL in glycolysis (see Fig. 264 ). See also ACETYLCOENZYME A. Pyruvic acid is broken down further, the precise reactions depending upon whether oxygen is present or not. See AEROBIC RESPIRATION, ANAEROBIC RESPIRATION.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
By using the same method, the treatment group was resuscitated with 50 ml of Ringer's sodium pyruvate solution (50 mM sodium pyruvate).
Pathologically speaking, septic shock is a complicated process manifested as hypotension that leads to severe prognosis by inducing insufficient oxygen supply and energy metabolism disorders in organs, tissues and cells.7 During metabolism and circulation, sodium pyruvate, through competitive inhibition, promotes the metabolism of the pentose phosphate pathway to generate NADPH and the recovery of glycometabolic oxidation.
Sodium pyruvate is superior to sodium lactate in correcting acidic environment at the early stage of severe shock because renal glycogen regeneration is subjected to compensatory enhancement Furthermore, sodium pyruvate prevents the generation of oxygen radicals by hindering the formation of peroxides, and eliminates them by reacting with H2O2 to yieldcentral venous oxygen saturation index and urine output were also improved after treatment, with significant inter-group differences also (Pless than 0.05), suggesting that Ringer's sodium pyruvate solution evidently relieved acidosis and benefited the reversal of refractory shock.
Serum TNF-a and IL-6 levels of both groups herein significantly decreased after treatment (Pless than 0.05), and the levels of the treatment group were significantly lower than those of the control group (Pless than 0.05), indicating that Ringer's sodium pyruvate solution inhibited the inflammatory response after septic shock, mitigated oxygen free radical-induced proinflammatory response, and enhanced free radical-scavenging capacity.