pyruvate carboxylase

Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to pyruvate carboxylase: gluconeogenesis

py·ru·vate car·box·yl·ase

ligase catalyzing reaction of ATP, pyruvate, and HCO32-, to form ADP, orthophosphate, and oxaloacetate; biotin and acetyl-CoA are involved; an absence of this enzyme results in neuronal loss in the cerebral cortex, leading to mental retardation.

pyruvate carboxylase

[pī′ro̅o̅·vāt kär·bok′sə·lās]
an enzyme that catalyzes the irreversible carboxylation of pyruvate, a reaction necessary for gluconeogenesis from lactate or amino acids forming pyruvate and also providing four-carbon compounds for the citric acid cycle. The enzyme is a mitochondrial protein occurring in liver but not in muscle. Deficiency of the enzyme, an autosomal-recessive trait, causes severe psychomotor retardation and lactic acidosis in infants. There is a particularly severe, rapidly fatal form, in which hyperammonemia, citrullinemia, and excess of lysine in the blood are also present.


a salt, ester or anion of pyruvic acid. The term is used interchangeably with pyruvic acid. Pyruvate is the end product of glycolysis and may be metabolized in the body to lactate or to acetyl CoA. In yeast it is metabolized to ethanol.

pyruvate carboxylase
an enzyme concerned in the conversion of pyruvate to oxaloacetic acid.
pyruvate dehydrogenase
actively concerned in the decarboxylation of pyruvate to acetyl CoA and CO2.
pyruvate kinase
a glycolytic pathway enzyme (called also PK) which catalyzes the formation of pyruvate from phosphoenolpyruvate (PEP). A deficiency of the enzyme is a hereditary defect in humans and occurs also in Beagle and Basenji dogs, causing a familial nonspherocytic anemia.
pyruvate transaminase
References in periodicals archive ?
1999) A method for the determination of pyruvate carboxylase activity during the glutamic acid fermentation with Corynebacterium glutamicum, Journal of Microbiological Methods 39: 91-96.
Liver samples (200 mg) were prepared for pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), peroxisome proliferators activated receptor-[alpha] (PPAR-[alpha]), and glucose transporter-2 (GLUT-2).
Furthermore, an increase in pyruvate carboxylase (PC) activity is evident under glutamate-overproducing conditions, which may lead to an increase in carbon flux from pyruvate to oxaloacetate.