Pyridium


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Pyridium

 [pĭ-rid´e-um]
trademark for preparations of phenazopyridine hydrochloride; a urinary tract analgesic.

phenazopyridine hydrochloride

AZO-Gesic, Azo-Standard, Baridium, Phenazo (CA), Prodium, Pyridium, ReAzo, UTI Relief

Pharmacologic class: Nonopioid analgesic

Therapeutic class: Urinary analgesic

Pregnancy risk category B

Action

Unknown. Thought to act locally on urinary tract mucosa to produce analgesic or anesthetic effects, relieving urinary burning, urgency, and frequency.

Availability

Tablets: 95 mg, 97.2 mg, 100 mg, 200 mg

Indications and dosages

Pain caused by lower urinary tract irritation

Adults: 200 mg P.O. t.i.d.

Children: 12 mg/kg P.O. daily in three divided doses

Contraindications

• Hypersensitivity to drug

• Renal insufficiency

Precautions

Use cautiously in:

• hepatitis

• pregnant or breastfeeding patients

• children younger than age 12.

Administration

• Give with or after meals.

• Discontinue after 2 days, as prescribed, when administering with antibiotics.

Adverse reactions

CNS: headache

EENT: contact lens staining

GI: GI disturbances

GU: bright orange urine, renal toxicity

Hepatic: hepatotoxicity

Hematologic: hemolytic anemia,

methemoglobinemia

Skin: rash, pruritus

Other: anaphylactoid-like reaction

Interactions

Drug-diagnostic tests. Bilirubin, glucose, ketones, protein, steroids: interference with urine tests based on spectrophotometry or color reactions

Patient monitoring

• Monitor patient for symptomatic improvement of urinary tract infection (UTI).

• Assess follow-up urine culture after antibiotic therapy ends.

Monitor for yellowing of skin or sclera. This change may indicate drug accumulation caused by impaired renal excretion, warranting drug withdrawal.

Patient teaching

• Explain drug therapy and measures to help prevent UTI recurrence.

• Tell patient drug may discolor urine and tears and may stain clothing and contact lenses.

Advise patient to contact pre-scriber promptly if symptoms don't improve or if skin or eyes become yellow.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

Pyridium

(pī-rĭd′ē-əm)
A trademark for the drug phenazopyridine hydrochloride.

Pyridium®

Butabarbital, see there.
References in periodicals archive ?
Methemoglobinemia due to ingestion of at most three pills of pyridium in a 2-year-old: case report and review.
Q Are there such things as Pyridium crystals in a urine sediment?
Orange: phenazopyridine (such as in Pyridium, a bladder "soother"); sulfasalazine (used to treat ulcerative colitis and other bowel problems)
Methylene blue (50 mg IV over a period of 5 minutes) appears to have been a common go-to dye for gynecologic surgeons, along with pyridium (a 200-mg oral dose prior to surgery), ever since production of indigo carmine was discontinued because of a lack of raw material.
To use this approach, administer one dose of phenazopyridine (Pyridium, AzoGesic), 100 mg or 200 mg orally, 30 minutes to 1 hour before the planned surgical start time, in the preoperative holding area.
Hinman identified high peri-pelvic and peri-ureteral concentrations of preoperatively administered Pyridium in the setting of iatrogenic ureteral obstruction.
Phenazopyridine, the chemical found in numerous OTC medications, such as Pyridium, AZO, and Uristat, was discovered by Swiss chemist Bernhard Joos in the 1950s.
To help determine whether this is the case, give the patient one Pyridium tablet to take in the morning; the Pyridium will cause her urine to turn orange.
Those with more severe symptoms may benefit from a urinary analgesic such as phenazopyridine (Pyridium [R]) or a combination agent such as Urised [R].
The possibility of an extended course of antibiotics (e.g., nitro-furantoin + pyridium for 2-3 weeks) therapy was also discussed as a means of ruling out an infectious etiology (given that her symptoms are episodic).
Initial investigations include a urinalysis and a 3-day voiding diary (grade C).[sup.2,21] In specific clinical situations, the following tests are recommended: symptoms/quality of life questionnaires (International Consultation on Incontinence Questionnaire [ICIQ] grade A, Incontinence Impact Questionnaire [IIQ]-7, Urogenital Distress Inventory [UDI]-6), pad weight testing, serum creatinine, uroflowmetry, post-void residual volume (PVR), methylene blue or pyridium pad testing, cystoscopy and urodynamic studies (UDS).[sup.18] Uroflowmetry and PVR assessment is recommended in the presence of significant voiding symptoms, symptomatic pelvic organ prolapse or bladder overdistension.