Giannobile, "C-telopeptide pyridinoline
total serum alkaline phosphatase; urinary pyridinoline
The pyridinium crosslinks formed (deoxypyridinoline or Dpd, and pyridinoline
or Pyd) act to strengthen the matrix, and are only found in mature collagen.
Assessment and recommendations of factors contributing to preanalytical variability of urinary pyridinoline
Such findings were then expressed in terms of peak ratios, with larger ratios reflecting an increase in the size and maturity of the crystals and an increase in the pyridinoline
cross-links in collagen, both of which reflect a deterioration in the quality of the bone matrix, Dr.
Differences in levels of urinary markers such as pyridinoline
and deoxypyridinoline between the treatment and placebo groups suggested a decrease in the rate of bone resorption.
Serum Vitamin D and Pyridinoline
Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis.
(PYD) and deoxy-pyridinoline (DPD) are specific cross-links formed within structural collagens between lysine or hydroxylysine residues in the telopeptide region with specific sites within the collagen triple helix, with PYD having 2 forms, hydroxylysyl PYD formed from 3 hydroxylysine residues and lysyl PYD which is derived from 1 lysine and 2 hydroxylysine residues.
The number of pyridinoline
cross-links and Hyl residues was expressed per collagenmolecule assuming 300 hydroxyproline residues per triple helix.
Comparison of free and peptide-bound pyridinoline
cross-links excretion in rheumatoid arthritis and osteoarthritis.
Bone densities at the femoral neck and lumbar spine were tested after 24 months, along with serum levels of bone-specific alkaline phosphatase, markers of bone turnover (urinary excretion of pyridinoline
and deoxypyridinoline), insulin-like growth factor 1 (IFG-1), and endometrial thickness.
The investigators noted a significant decrease in bone turnover in the alendronate group, as measured by significantly higher urine pyridinoline
and urine deoxypyridinoline levels.