Comparison of biochemical markers of bone turnover in Paget disease treated with pamidronate and a proposed model for the relationships between measurements of the different forms of pyridinoline
total serum alkaline phosphatase; urinary pyridinoline
Levels of the bone and cartilage component pyridinoline
were measured to evaluate this biomarker as an indicator of joint destruction in serum samples from 437 early RA patients from the Leiden Early Arthritis Cohort.
6 The recommended laboratory test to diagnose ky-phoscoliosis type of Ehlers-Danlos syndrome is the measurement of total urinary hydroxylvsyl pyridinoline
") and lysyl pyridinoline
("Deoxypyridinoline") crosslinks after hydrolysis by HPLC, a test with very high degree of sensitivity and specificity.
(pyr) and deoxypyridinoline (dpyr) are the two nonreducible pyridinium cross-links present in the mature form of collagen.
The final results announced today contain data for three bone break down markers namely, deoxypyridinoline ("DPD"), pyridinoline
("PYD") and CrossLaps(TM) which are recognized as being the most reliable bone markers of high bone turn over.
It will be important to document that the amino-terminal peptide of collagen cross-links (NTX), pyridinoline
(PYD), or deoxypyridinoline (DPD) perform as well when subjected to such rigorous study.
Resorption markers, including urinary pyridinoline
and deoxypyridinoline (such as those marketed by Metra Biosystems, MTRA), correlated nonsignificantly (r approximately -0.
We recently reported (8) that the (3-CrossLaps assay for serum Cterminal telopeptide of type I collagen ([beta]-CTX) (9-11) provides values that are no less significant than those for pyridinoline
(PYD) and deoxypyridinoline (DPD), 2 commonly used serum bone resorption markers, in assessing bone metabolism in HD patients.
Metra's assays measure the pyridinium crosslinks of collagen, pyridinoline
(Pyd) and deoxypyridinoline (Dpd).
The least significant change amounts for bone alkaline phosphatase (AP), osteocalcin, pyridinoline
, deoxypyridinoline, and N-telopeptide are in the range of 15% to 40% (20).
Specific degradation products of the bone matrix, such as DPD and pyridinoline
(PYD), closely reflect the rate of bone metabolism.