The first group is IgE-mediated immediate hypersensitivity reactions, especially associated with iodinated contrast media, beta-lactam antibiotics, neuromuscular blocking agents, quinolones and pyrazolones
. The second includes the adverse effects of NSAIDs due to inhibition of cyclooxygenase resulting in major alterations in arachidonic acid metabolism and is generally non-allergic.
Levy, "Hypersensitivity to pyrazolones
," Thorax, vol.
Laufersweiler et al., "Development of orally bioavailable bicyclic pyrazolones
as inhibitors of tumor necrosis factor-a production," Journal of Medicinal Chemistry, vol.
Manoj, "Study on antibacterial activity for multidrug resistance stain by using phenyl pyrazolones
substituted 3-amino [sup.1]H-pyrazolon(3, 4-b) quinoline derivative in vitro condition," International Journal of Pharmtech Research, vol.
Nonsteroidal anti-inflammatory drugs (NSAIDs) (with the exception of pyrazolones
) are believed to rarely be among the causes of IgE-mediated anaphylaxis, but such anaphylaxis is more commonly related to an aberrant arachidonic acid metabolism [20-22].
The physicochemical methods, such as 4-AAP and FCR, are based on the phenols providing an intense red color development of the pyrazolones
group, with maximum absorption in the wavelength of 510 nm.
Among the patients, 51.6% reacted to multiple COX-1 inhibitors and 13.9% convincingly reacted to a single drug (aspirin, pyrazolones
, or diclofenac).
Surati, "Synthesis, characterization and crystal structure of some bidentate heterocyclic Schiff base ligands of 4-toluoyl pyrazolones
and its mononuclear Cu(II) complexes," Journal of Molecular Structure, vol.
NSAIDs commercial can be grouped, based on a chemical point of view, into three main classes: (1) carboxylic acids, (2) phenazones (pyrazolones
, oxicams), and (3) nonacidic compounds.
Synthesis of rigid pyrazolones
," Bioorganic and Medicinal Chemistry, vol.
Figure 6 displays the powder diffraction patterns for the benzimidazolones PY151, PY154, and PO36, while the pyrazolones
PO13 and PR41 are shown in Fig.
(Jensen 1959, Zolotov et al 1966, 1968, Karalova and Pyzhova 1968, Monseev and Monokhov 1968) have been shown to be good extraction reagents for metals in acidic solutions.