There also are reports of increased MAP-2 expression in the cerebral cortex of patients with early stage Alzheimer's disease (Mukateba-Ladinska et al., 2000) and in the pyramidal neurons
of the cerebral cortex of patients with cortical dysplasia associated with cases of intractable epilepsy (Yamanouchi et al., 1996).
They also have reported that the [beta]-arrestin2 knockout mice have a deficiency in long-term potentiation (LTP) induced by low-frequency stimulation, paired stimulation of mossy fiber inputs to CA3 pyramidal neurons
, but not in LTP induced by high-frequency stimulation .
I aim to determine the mechanisms mediating the allocation of interneurons born in the caudal ganglionic eminence (CGE) into circuits composed of pyramidal neurons
and interneurons in the cerebral cortex.
In this respect, some evidence indicates that calbindin expression in non pyramidal neurons
decreases during the second and third postnatal weeks in parallel with the onset of PV immunoreactivity (Alcantara et al.
In addition, repeated restraint stress induces a decrease in number and length of apical dendrites and spine synapses in pyramidal neurons
of the mPFC .
Given their key role in cognition and their potential involvement in the pathophysiology of psychiatric disorders, I propose to manipulate GR expression within PFC pyramidal neurons
and Parvalbumin-expressing interneurons.
Chronic stress could induce retraction in apical dendrites and loss in dendritic spines in both layers II/III and layer V mPFC pyramidal neurons
Of special importance for this integration are the distal apical dendrites of cortical pyramidal neurons
because top-down fibers target layer 1 of the cortex which are densely innervated by these structures.
Voipio, "Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons
of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent [K.sup.+] transient," Journal of Neuroscience, vol.
Here I propose the use of cutting edge technology, including the ultrasensitive LOTOS procedure of in vivo two-photon calcium imaging that was developed in our laboratory, to investigate for the first time the functional properties and the plasticity of signal synapses in auditory cortical pyramidal neurons
of layers 2/3, 4 and 5 in vivo.
Gu and colleagues have reported differences in SK channel regulation of neuronal excitability between CA1 neurons and bursting pyramidal neurons
In CA3, the highest density is found in the stratum lucidum, where mossy fibers of DG granule cells make synapses on pyramidal neurons
. In DG, it is the highest in the polymorph layer in the hilus and the lowest in the granule cell layer (but see ).