, pigmented villonodular synovitis, hemophilic arthropathy, rheumatoid arthritis, osteochondromatosis, and neoplasms should be considered in the differential diagnosis of patients with elbow involvement (15).
Inflammatory bowel disease--Crohn's disease, ulcerative colitis Hematologic disorders Hematologic malignancy Multiple myeloma Myelodysplasia Polycythemia vera Arthritis Rheumatoid arthritis Seronegative arthritis Inherited autoinflammatory syndromes  PAPA PAPASH SAPHO AML, acute myeloid leukemia; PAPA, pyogenic arthritis
, pyoderma gangrenosum, and acne; PAPASH, pyogenic arthritis
, pyoderma gangrenosum, acne, and hidradenitis suppurativa; SAPHO, synovitis, acne, pustulosis, hyperostosis, and osteitis.
Antibiotics were discontinued given that these findings were inconsistent with pyogenic arthritis
, and she was improving clinically.
They also recognized a range of associated disorders, including SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis), PAPA syndrome (pyogenic arthritis
, pyoderma gangrenosum, and acne), and PASH (pyoderma gangrenosum, acne, and hidradenitis suppurativa).
Bony Abnormalities Tuberculosis Pyogenic HongS H et Present Hong SH Present MRI Findings al (11) Study et al (11) Study Bona Erosion 83% 44% 46% 0% Marrow Signal 59% 78% 92% 100% Abnormality In our study, we found bone erosion to be much more common with tuberculous than with pyogenic arthritis
. The marrow signal abnormality change is seen in accordance to the findings obtained by Hong SH et al (11) who found significantly larger percentage of marrow signal abnormalities in pyogenic arthritis
Flipo et al., "Peripheral pyogenic arthritis
. A study of one hundred seventy-nine cases, " Revue du Rhumatisme, vol.
Certain syndromes, in which HS is a part of the clinical picture, are precisely defined, for example, pyogenic arthritis
, pyodermia gangrenosum, acne and hidradenitis suppurativa (PAPASH) "PASH", Pyogenic Arthritis
, Pyoderma gangrenosum and Acne (PAPA) and others have been noted earlier, too.
pyoderma###CD2-binding protein 1###Arthritis and pyoderma###Oral antibiotics IL-
SAIDs presenting with nonbacterial pyogenic manifestations include pyogenic arthritis
, pyoderma gangrenosum and acne (PAPA) syndrome, deficiency of the IL-1-receptor antagonist, deficiency of the IL-36 receptor antagonist, Majeed syndrome, and chronic recurrent multifocal osteomyelitis.
To date, there are twelve known MAISs: familial Mediterranean fever (FMF); tumor necrosis factor receptor-associated periodic syndrome (TRAPS); cryopyrin-associated periodic syndrome (CAPS), a group which includes familial cold urticaria syndrome (FCAS), Muckle-Wells syndrome (MWS), and chronic infantile neurological cutaneous articular (CINCA) syndrome; mevalonate kinase deficiency (MKD); NLRP12-associated autoinflammatory disorder (NLRP12AD); granulomatous MAISs which include Blau syndrome (BS) and early-onset sarcoidosis (EOS); and, finally, the hereditary pyogenic disorders including PAPA (pyogenic arthritis
, pyoderma gangrenosum, and acne) syndrome, Majeed syndrome (MS), and deficiency of the IL-1 receptor antagonist (DIRA).
Familial cases of SAPHO syndrome have been described (15,16); however, genetic analyses fail to demonstrate variations in the coding regions or splice sites of genes known to cause auto-inflammatory bone disorders (e.g., Majeed syndrome, murine CRMO and cherubism), other skin inflammatory disorders (e.g., PAPA syndrome: pyogenic arthritis
, pyoderma gangrenosum, and acne), and mutations in NADPH oxidase (NCF4 gene).