Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein.
Puumala virus outbreak in western Thuringia, Germany, 2010: epidemiology and strain identification.
Phylogenetic tree based on complete nucleocapsid gene sequences of Puumala virus
(PUUV) strains from Lithuania (LT), Latvia (Jelgava1), and other PUUV clades.
Samples were initially submitted to determine antibodies against either a panel of agents causing neurologic infections (4,214 serum and 832 CSF samples), Puumala virus
(3,574 serum samples), or INKV (173 serum samples) (Table 1).
Distinguish long-term sequelae of acute nephropathia epidemica associated with Puumala virus
Prevalence of serum IgG antibodies to Puumala virus
(haemorrhagic fever with renal syndrome) in northern Sweden.
1 Puumala virus
IgG ND Negative ND ND ND Immunoblot Puumala virus
IgM ND Positive# ND ND ND Immunoblot Dobrava virus IgG ND Negative ND ND ND Immunoblot Dobrava virus IgM ND Negative ND ND ND Immunoblot Hantaan virus IgG ND Negative ND ND ND Immunoblot Hantaan virus IgM ND Negative ND ND ND Immunoblot * Bold font indicates positive results.
HFRS is caused by the prototypic hantavirus Hantaan and by Dobrava virus, Puumala virus
(PUUV), and Seoul virus in Eurasia; HCPS is caused by Andes virus, Sin Nombre virus and related hantaviruses in the Americas.
Phylogenetic analysis confirmed that the hantavirus involved belonged to Puumala virus
species and was most closely related to the earlier described genetic variants from Finland, particularly to those circulating at Konnevesi (62[degrees]34'N, 26[degrees]24'E) and Puumala (61[degrees]52'N, 28[degrees]17'E) localities (Figure 2).
Although 3 hantaviruses, Puumala virus
(PUUV), Dobrava-Belgrade virus, and Tula virus circulate in rodent hosts in Germany and can infect humans (6-8), most hantavirus infections in humans are caused by PUUV.