Phylogenetic tree constructed using the maximum-likelihood approach based on the complete small-segment RNA nucleotide coding sequences of representative Puumala virus
(PUUV) strains detected in human cases in France, 2012-2016 (circles), and on those published and representative of PUUV strains detected in Europe.
A major antigenic domain for the human humoral response to puumala virus
nucleocapsid protein is located at the amino-terminus.
Urinary neutrophil gelatinase-associated lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus
at NRC ([double dagger]) IgM PUUV 1 - 2 - ND 3 - ND * E, equivocal; IFA, indirect fluorescent antibody; ND, not done; NRC, National Reference Center for Hantavirus (Lyon, France); PUUV, Puumala virus
, SEOV, Seoul virus; +, positive; -, negative.
ADLV, Adler virus; CATV, Catacamas virus; HOKV, Hokkaido virus; KBRV, Khabarovsk virus; LNV, Laguna Negra virus; PHV, Prospect Hill virus; PUUV, Puumala virus
; TULV, Tula virus.
Phylogenetic analysis of Puumala virus
subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein.
Reservoir-driven heterogeneous distribution of recorded human Puumala virus
cases in South-West Germany.
Of the total 8,793 samples we tested for California serogroup virus IgM, 4,214 serum samples and 832 cerebrospinal fluid (CSF) samples had been initially sent for screening of meningoencephalitis agents; 3,574 serum samples had been initially sent for Puumala virus
testing; and 173 serum samples had been sent for INKV testing.
All serum samples exhibited substantially higher neutralizing titers toward DOBV than toward Puumala virus
, Hantaan virus, and Seoul virus.
(PUUV), by far the most frequent cause of hantavirus disease in Germany (7), causes a milder form of HFRS (8) called nephropathia epidemica (NE).
Five hantaviruses circulate among rodents in Europe, but most human HFRS cases are caused by Puumala virus
RNA has been detected by RT-PCR but not by cell culture in saliva from patients who had hemorrhagic fever with renal syndrome (29).