(B) Multiple neighboring Purkinje cells
are segmentally necrotic, indicated by the presence of shrunken, angular, and hypereosinophilic nuclei (*) (Scale bar = 50 [micro]m).
In the new paper, the researchers took their observations to humans, studying Purkinje cells
derived from three patients with TSC (two also had ASD symptoms, and all three also had epilepsy).
The cortex further has three layers-molecular, Purkinje cell
layer and granule cell layer.
Hayashi et al., "[alpha]-Synuclein accumulates in Purkinje cells
in Lewy body disease but not in multiple system atrophy," Journal of Neuropathology and Experimental Neurology, vol.
Greenlee, "Cerebellar Purkinje cells
incorporate immunoglobulins and immunotoxins in vitro: implications for human neurological disease and immunotherapeutics," Journal of Neuroinflammation, vol.
The internal granular cell neuron layer was enlarged, separated by increased neuropil with scanty Purkinje cells
. The cerebellar molecular layer was thickened with an abundance of radial processes.
All three trimester binge alcohol exposure causes fetal cerebellar purkinje cell
loss in the presence of maternal hypercapnea, acidemia, and normoxemia: Ovine model.
Cell counts were made by measuring a line in the monolayer of Purkinje cell
, and an index was obtained considering number of Purkinje cells
per lineal extent ([micro]m).
* P < 0.05 Table 2: Comparison of stereological parameters in the cerebellum of noise-exposed (NE) and respective controls at postnatal day 22 Control (n = 8) NE (n = 8) Volume ([mm.sup.3]) Molecular layer 35.5 [+ or -] 2.1 34.6 [+ or -] 1.0 Granular layer 27.0 [+ or -] 1.3 25.4 [+ or -] 1.2 White matter 22.1 [+ or -] 1.2 21.6 [+ or -] 0.7 Total number (x 106) Granule cells 41.4 [+ or -] 4.5 35.5 [+ or -] 2.3 Somal volume ([micro] [m.sup.3]) Purkinje cell
3699 [+ or -] 236 3128 [+ or -] 398 P value Volume ([mm.sup.3]) Molecular layer 0.29 Granular layer 0.02 White matter 0.34 Total number (x 106) Granule cells 0.005 Somal volume ([micro] [m.sup.3]) Purkinje cell
0.004 All value are expressed as mean [+ or -] SD
Toxin-produced Purkinje cell
death: a model for neural stem cell transplantation studies.
Sugimori, "Electrophysiological properties of in vitro Purkinje cell
somata in mammalian cerebellar slices," The Journal of Physiology, vol.
Verkerk's sinoatrial model , Butters's atrial model , O'Hara's ventricular model , and Li's Purkinje cell
model , and so forth, all belong to HH model type.