PtdIns is also a precursor of phosphoinositides by reversible phosphorylation of the inositol ring in different positions (3,4,5), resulting in generation of seven phosphoinositide species , among which phosphatidylinositol 4P (PtdIns-4P) and phosphatidylinositol 4,5 bisphosphate (PtdIns 4,5P) are the most studied.
The PtdIns signaling pathway through inositol triphosphate (insP3) seems to regulate this oocyte maturation stage [58,59].
Greenwood, JA, Theibert, AB, Prestwich, GD, Murphy-Ullrich, JE, "Restructuring of Focal Adhesion Plaques by PI 3-kinase: Regulation by Ptdins
(3,4,5)-p-3 Binding to Alpha-Actinin.
Tarasachi, a member of the research team, told SCIENCE NEWS that they currently are studying the structure of PtdIns
to explain its protective role, and that similar experiments using human blood are under way.
Figure 7 shows the immunoblot analysis of the low-speed Triton insoluble cytoskeletal fraction of nickel-stimulated platelets using a polyclonal antibody directed against the p85 subunit of PIK, closely correlated with PtdIns 3-kinase enzymatic activity in platelets (18).
PtdIns 3-kinase is known to translocate from the cytosol to the membrane cytoskeleton in the absence of fibrinogen only after vWf stimulation of platelets, with the ensuing activation of GpIb-V-IX complex, whereas stimulation with agonists such as ADP, epinephrine, or collagen has no such effect (14).
2]-induced cytoskeletal association of PtdIns 3-kinase strongly supports the idea that Ni[Cl.
Signals received by some of these membrane receptors trigger the PtdIns cycle into action.
The more trigger molecules there are in the fluids surrounding PtdIns-containing cells, the more cycles the PtdIns cycle runs through, and presumably the more intense or prolonged will be the associated physiological responses.
15) results of a preliminary study designed to test if lithium's PtdIns connection, which was demonstrated earlier by William R.
The scientists conclude that lithium can indeed affect neurotransmitter responses via the PtdIns cycle.
Now the Hopkins scientists are conducting experiments to see if the mischief perpetrated by lithium on the PtdIns system has an effect on brain cells; if so, it might explain lithium's demonstrated ability to moderate extreme moods of different kinds.