We report striking region-specific effects of sex steroid hormones and BDNF genotype on hippocampal NMDA-R and PSD-95
The primary antibody was mice-anti-Rat GluA1/2/3/PICK-1/ PSD-95
(Millipore, 1: 100).
To our surprise, distribution of PSD-95
puncta at two time points was markedly different, even if the time interval was set to be 24 h (Fig.
In addition to boosting overall tissue viability, we showed that RA-NP treatment protected neurons from LPS-induced injury by normalizing enolase and PSD-95
Growing evidence shows that A[beta]O induce depletion of hippocampal synaptic proteins such as SYN and PSD-95
, resulting in memory dysfunction in
Effect of ICA on PSD-95
, BDNF, pTrkB, pAkt, and pCREB Protein Expressions in the Hippocampi of A[[beta].sub.1-42]-Infused Rats.
is a membrane-associated kinase concentrated at glutamatergic synapses.
Delineation of additional PSD-95
binding domains with NMDA receptor NR2 subunits reveals differences between NR2A/PSD-95 and NR2B/PSD-95 association.
In order to find compounds that can detach the PSD-95
protein from the NMDA receptor, one must have a method for measuring the extent to which the compounds bind to PSD-95
Significant changes in protein levels of NMDA receptor subunits NR1 and NR2A, and NMDA receptor interacting proteins PSD-95
and SAP97 were not detected.
Key words: nitric oxide synthase, NMDA receptor, PDZ domain, PSD-95
, Scutellaria baicalensis Georgi, Labiatae, stroke, traditional Chinese medicine, TCM
The CDKL5 substrates that have, so far, been identified are MeCP2 [11, 12], DNA methyltransferase 1 (DNMT1) , Rac1 , amphiphysin 1 , PSD-95
, NGL-1 , Mind Bomb 1 (Mib1) , Shootin1 , HDAC4 , and IQGAP1 .