DLG4

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DLG4

A gene on chromosome 17p13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family that forms a complex with another MAGUK, DLG2, and is recruited into NMDA receptor and potassium channel clusters. DLG2 and DLG4 may interact at postsynaptic sites to form a multimeric scaffold for clustering of receptors, ion channels and signalling proteins.
References in periodicals archive ?
Application of PSD-95-GFP as a second marker of postsynaptic specialization was already proven to be useful in culture preparations, and recent studies have demonstrated reliable detection of synapse-containing spines by double imaging of the spine structure and PSD-95 clusters (Fig.
Our group performed thin skull window-based in vivo two-photon imaging of spines at postnatal 2 and 3 weeks and found extensive gain and loss of both spines and PSD-95 clusters (Fig.
Indeed, these three mouse models show consistent upregulation in the turnover of spines positively associated with PSD-95 clusters (Fig.
In rats that drank water with added fluoride for several months, the fluidity of brain synaptic membranes and the expression level of PSD-95 decreased in a dose-dependent manner.
5% sevoflurane, a fluoride-based anesthetic, showed long-term deficits in hippocampal function and decreased hippocampal PSD-95 expression.
found that autism spectrum disorder is related to ER stress induced by mutations in the genes encoding synaptic cell adhesion molecules, and that PSD-95 is involved.
Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development.
Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95.
He added that scientists have committed many resources to finding out exactly how the compounds bind to PSD-95 - using for example sophisticated biophysical methods.
In this study, we used NMR (nuclear magnetic resonance) spectroscopy and the chemical shift perturbation approach to screen TCM stroke drugs for active components that are capable of binding to the second postsynaptic density 95(PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95, the scaffold protein linking nNOS and PSD-95 at the postsynaptic membrane of neurons (Brenman et al.
Using NMR spectroscopy, we found that certain compounds from aqueous extracts of Huangqin, the root of Scutellaria baicalensis Georgi (Labiatae) bound to the second PDZ domain of PSD-95.
Briefly, the pET14b plasmids containing PDZ2 of PSD-95 were transformed into Escherichia coli BL21 (DE3) by electroporation.