Plasma cell dyscrasia with kappa light-chain crystals in proximal tubular
cells: a histological, immunofluorescent, and ultrastructural study.
Dent's disease is rare recessive X-linked renal tubular disorder manifesting by proximal tubular
dysfunction of different grades, nephrolithiasis, nephrocalcinosis, rickets and slowly progressive renal failure.
In the early stages of CsA administration kidney damage can occur, which causes alterations in intrarenal hemodynamics related to afferent arteriolar vasoconstriction, causing a decrease in glomerular filtration rate, renal plasma flow, loss of proximal tubular
cells brush border, proximal tubule dilatation, swelling, necrosis, and infiltration of white blood cells in the kidney cortex.
Citation: "Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm that Forms Tubules Expressing Kidney Proximal Tubular
Markers"; Albert Q.
Results of this study indicated that HOCM have a greater potential for cytotoxic effects on proximal tubular
cells in vitro than do LOCM or IOCM.
have shown that, in cultures of proximal tubular
cells, ANP inhibits the inducible nitric oxide synthase (iNOS) activity, via NPRC and cGMP .
KIM-1 mRNA and protein are expressed at low levels in normal kidney but are specifically up regulated in de-differentiated proximal tubular
cells after ischemic or nephrotoxic acute kidney injury (AKI).
Results showed that the renal proximal tubular-like cells generated by IBN were similar to the renal proximal tubular
cells isolated from fresh human kidney samples.
Of the different types of RTA associated with hypokalemia, distal RTA may be due to a defect in proximal tubular
reabsorption found in the bicarbonate ion (HC[O.sub.3]) in type 2 RTA or a defect involving impaired distal tubular [H.sup.+] secretion in [H.sup.+]-ATPase/[H.sup.+][K.sup.+] ATPase (type 1 RTA).
Certain proximal tubular
cells demonstrated varying degree of necrosis.
Mellittin act on the apical membrane cell transporters of proximal tubular
cell of the kidney thus reduce the cell viability and inhibit the activity of renal transporter.
High glucose (HG) stimulated cultured human renal proximal tubular
epithelial cells (HK-2) analyzed CTGF expression by Western blotting and investigated whether extracellular signal-regulated kinase (ERK) signaling pathway was involved.