Provigil


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modafinil

Alertec (CA), Apo-Mofafinil (CA), Provigil

Pharmacologic class: Nonamphetamine CNS stimulant

Therapeutic class: Analeptic

Controlled substance schedule IV

Pregnancy risk category C

Action

Unknown. Thought to stimulate CNS by decreasing the release of gamma-aminobutyric acid (a CNS depressant), thereby increasing mental alertness.

Availability

Tablets: 100 mg, 200 mg

Indications and dosages

Narcolepsy

Adults: 200 mg/day P.O. as a single dose in morning

Dosage adjustment

• Severe hepatic impairment

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• recent myocardial infarction, unstable angina, severe hepatic impairment, hyperthyroidism, hypertension, glaucoma, anxiety

• history of left ventricular hypertrophy, ischemic ECG changes, chest pain, arrhythmias, or mitral valve prolapse with previous CNS stimulant use

• history of psychosis

• drug abuse

• pregnant or breastfeeding patients

• children (safety and efficacy not established).

Administration

• Give without food (food delays drug absorption).

Adverse reactions

CNS: headache, dizziness, nervousness, insomnia, depression, anxiety, amnesia, tremor, emotional lability

CV: hypertension, chest pain, vasodilation, hypotension, syncope, arrhythmias

EENT: abnormal vision, amblyopia, epistaxis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, dry mouth, anorexia

GU: abnormal urine, urinary retention, albuminuria, abnormal ejaculation

Hematologic: eosinophilia

Metabolic: hyperglycemia

Musculoskeletal: joint disorders, neck pain and rigidity

Respiratory: lung disorder, dyspnea, asthma

Skin: dry skin

Other: fever, chills, herpes simplex infection

Interactions

Drug-drug. Carbamazepine, phenobarbital, rifampin, other CYP3A4 inducers: decreased modafinil blood level

Cyclosporine, theophylline: decreased blood levels of these drugs

Diazepam, phenytoin, propranolol, tricyclic antidepressants, warfarin: increased blood levels of these drugs

Hormonal contraceptives: decreased contraceptive efficacy

Itraconazole, ketoconazole, other CYP3A4 inhibitors: increased modafinil blood level

Methylphenidate: delayed modafinil absorption

Drug-diagnostic tests. Aspartate aminotransferase, eosinophils, gamma-glutamyl transferase, glucose: increased levels

Hepatic enzymes: abnormal levels

Patient monitoring

• Monitor respiratory and cardiovascular status, including vital signs and ECG.

• Monitor neurologic status, including mood, motor function, cognition, and emotional lability.

• Monitor blood glucose level in diabetic patient.

• Monitor patient carefully if he is also receiving MAO inhibitors. (However, interaction studies with MAO inhibitors haven't been done.)

Patient teaching

• Tell patient he may take with or without food, but that food may delay drug absorption up to 1 hour.

Advise patient to immediately report chest pain, irregular heart beats, light-headedness, or fainting.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, vision, motor function, and alertness.

• Instruct female patient to use reliable nonhormonal contraception during and for 1 month after therapy.

• Tell diabetic patient to monitor blood glucose level closely and stay alert for hyperglycemia.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Provigil

(prō-vĭj′əl)
A trademark for the drug modafinil.

Provigil®

Modafinil, see there.

Provigil

A brand name for MODAFINIL.
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References in periodicals archive ?
The National Pregnancy Registry of Psychostimulants (866-961-2388) is studying amphetamine (Adderall), dextroamphetamine (Dexedrine and Focalin), lisdexamfetamine (Vyvanse), methylphenidate (Concerta, Daytrana, Desoxyn, Ritalin), and modafinil (Provigil).
Soon after, 1 learned on a Psychiatry Network Facebook discussion that generic Provigil is not expensive at all!
in 2011, had improperly delayed the introduction of a generic competitor to Provigil. In addition to Cephalon and Mylan, the suit named Teva and Ranbaxy Laboratories Ltd.
[Time, Place]: Provigil is the most effective remedy for sleep disorders and also for enhancing wakefulness in men and women.
Provigil is a drug that treats sleep disorders, and as of 2011, it made more than $1 billion in sales.
While Dexedrine and Provigil may keep soldiers awake for extended periods of time--studies have found that service members on Provigil can remain awake for more than eighty hours straight--complications have arisen as to what a soldier experiences when alertness begins to fade.
Prominent CEDs include methylphenidate (Ritalin is a brand name), modafinil (Provigil is a brand name), and that great staple in life, caffeine.
Effexor (venlafaxine) and Provigil (modafaxii1) are other non-stimulants used off-label; neither has been well studied in adult ADHD, according to Dr.
Silicon Valley start-up executives have also been tampering with their nervous systems in the hope of boosting productivity Provigil, which is manufactured by the Frazer, Pennsylvania-based drug-maker Cephalon, is designed to improve wakefulness and has been approved for prescription by the Food and Drug Administrator as a treatment for narcolepsy, obstructive sleep disorders and those who cannot sleep because of shift-work patterns.
Modafinil, marketed as Provigil in the US, is a prescription-only drug used to improve wakefulness in those who suffer from sleep disorders like narcolepsy.
PROVIGIL Modafinil is a treatment for narcolepsy or sleeping sickness that is also taken by fatigued multiple sclerosis sufferers.
* A new study by Lianne Schmaal at the University of Amsterdam suggests that Modafinil (Provigil), a drug originally developed to increase wakefulness, may help some people to reduce drinking by improving their impulse control.