trimethoprim(redirected from Protrin DF)
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an oral antibacterial closely related to pyrimethamine, almost always administered in combination with a sulfonamide, primarily for treatment of urinary tract infections. The sulfate salt is applied topically to the conjunctiva, in combination with polymyxin B sulfate, in the treatment of ocular infections.
An antimicrobial agent that potentiates the effect of sulfonamides and sulfones; usually used in combination with sulfamethoxazole.
An antibiotic drug, C14H18N4O3, used primarily to treat or prevent urinary tract infections, often in combination with sulfamethoxazole.
sulfamethoxazole/trimethoprimBactrim, see there.
An antimicrobial agent that potentiates the effect of sulfonamides and sulfones; usually used in combination with sulfamethoxazole (TMP/SMX).
trimethoprimAn antibacterial drug used to treat urinary and other infections. The drug is on the WHO official list. Brand names are Ipral, Monotrim and Trimopan. Combined with sulphamethoxazole it is sold as co-trimoxazole (Septrin) and Chemotrim.
1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.
An antimicrobial agent that potentiates effect of sulfonamides and sulfones.