proton pump


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pump

 [pump]
1. an apparatus for drawing or forcing liquid or gas.
2. to draw or force liquids or gases.
blood pump a machine used to propel blood through the tubing of extracorporeal circulation devices.
breast pump a pump for taking milk from the breast.
calcium pump the mechanism of active transport of calcium (Ca2+) across a membrane, as of the sarcoplasmic reticulum of muscle cells, against a concentration gradient; the mechanism is driven by hydrolysis of ATP.
enteral feeding pump an infusion pump specifically designed for administration of a solution through a feeding tube.
insulin pump see insulin pump.
intra-aortic balloon pump see intra-aortic balloon pump.
muscle pump compression of veins by the contraction of skeletal muscles, forcing blood towards the heart against the flow of gravity; seen particularly in the deep veins of the lower limbs. Called also venous pump.
proton pump a system for transporting protons across cell membranes, often exchanging them for other positively charged ions.
sodium pump (sodium-potassium pump) the mechanism of active transport driven by the energy generated by Na+,K+-ATPase, by which sodium (Na+) is extruded from a cell and potassium (K+) is brought in, so as to maintain the low concentration of sodium and the high concentration of potassium within the cell with respect to the surrounding medium. A high concentration of intracellular potassium is necessary for vital processes such as protein biosynthesis, certain enzyme activities, and maintenance of the membrane potential of excitable cells. Called also Na+-K+ pump.
stomach pump see stomach pump.
venous pump muscle pump.

pro·ton pump

molecular mechanism for the net transport of protons across a membrane; usually involves the activity of an ATPase.

proton pump

An ATP-dependent H+ ion transporter present in the membranes of lysosomes and vacuoles, which maintains a low pH (4.5-5.0) inside these organelles. Proton pumping is also required in the electron transport chain, where an NADH (or FADH) is oxidised to NAD+ (or FAH+), releasing 2 electrons and a proton.

pro·ton pump

(prō'ton pŭmp)
Molecular mechanism for the net transport of protons across a membrane; usually involves the activity of adenosine triphosphatase.

proton pump

a specialized assembly of proteins in a cell membrane which transports protons against a concentration gradient.
References in periodicals archive ?
Once Versus Twice-Daily Oral Proton Pump Inhibitor Therapy for Prevention of Peptic Ulcer Rebleeding: A Propensity Score-Matched Analysis.
How should Helicobacter pylori eradication be done in the extensive proton pump inhibitor allergy?
More than a quarter of a century ago, people with gastroesophageal reflux disease (GERD, or heartburn) thought they'd found a true "magic medicine" in new proton pump inhibitor(PPI) drugs.
Assessing the risk of hospital-acquired clostridium difficile infection with proton pump inhibitor use: a meta-analysis.
Keywords: Hospital acquired pneumonia, Proton pump inhibitors, Stress ulcer prophylaxis.
Several studies have shown long-term side effects with PPI use, including risk of clostridium difficile colitis and dementia; although the evidence is still controversial, the overuse of proton pump inhibitor has been proven by multiple studies.
"Our findings do not support previous assumptions that long-term proton pump inhibitor use would be associated with an increased risk of hip fractures," the authors write.
The patient was evaluated by a neurosurgeon who recommended 6-8 weeks of cervical collar and treatment with dexamethasone along with proton pump inhibitor (PPI) for ulcer prophylaxis.
Hajjar, "Proton pump inhibitors and risk of mild cognitive impairment and dementia," Journal of the American Geriatrics Society, vol.
Caption: Proton pump inhibitors (PPIs) and diuretics are two medications that can interfere with nutrient absorption.
The prevalence of this condition in Japan is estimated to be 10%.(1) In many cases, 8 weeks of initial treatment followed by maintenance therapy with a once-daily proton pump inhibitor is sufficient to cure reflux esophagitis and prevent remission.