prothrombin complex concentrate

(redirected from Prothrombin complex)


1. to bring to a common center; to gather at one point.
2. to increase the strength by diminishing the bulk of, as of a liquid; to condense.
3. a drug or other preparation that has been strengthened by evaporation of its nonactive parts.
activated prothrombin complex concentrate (APCC) anti-inhibitor coagulant complex.
prothrombin complex concentrate (PCC) factor IX complex.

prothrombin complex concentrate (PCC)

prothrombin complex concentrate

Hematology Any commercial product–eg, FEIBA–Factor VIII inhibitor by-passing activity that contain nonactivated factors IX, in addition to II, XI and X; PCCs may be used to ameliorate the intensity and duration of joint and soft tissue bleeding in hemophiliacs who produce factor VIII inhibitors; PCCs are 50% effective in staunching hemorrhage. See Prothrombin.
References in periodicals archive ?
While data are limited, prothrombin complex concentrate may be given for patients on rivaroxaban, apixaban, or edoxaban who are experiencing an intracranial hemorrhage or other form of severe bleeding.
Electronic Auction: Delivery of coagulation factors II, VII, IX and X in combination Prothrombin Complex for the needs of the Federal Service for Health Care and Social Development of the Russian Federation Ministry of Health (Chelyabinsk)
Fresh frozen plasma, prothrombin complex concentrates, and recombinant activated factor VII have been used to treat acute hemorrhage in FV inhibitor cases with varying outcomes.
The antidotes available in the market include vitamin K, protamine, and prothrombin complex concentrates, which reverse the action of warfarin and heparin.
Antidotes are vit K parenteral and prothrombin complex concentrates.
The statement read: "It is our understanding that a patient experienced a serious rectal haemorrhage (the first reported SAE) and received bypassing agents, including repeated doses of activated prothrombin complex (aPCC), after which the patient developed signs of Thrombotic Microangiopathy (TMA, the second SAE).
The overall mortality associated with anticoagulation-associated ICH is higher than average and is variously reported at 42%-67%, even with prothrombin complex concentrate (PCC) therapy (Le Roux et al.
Prothrombin complex concentrates (PCCs) have become the new standard of care in managing hemorrhage in patients receiving warfarin anticoagulation.
Sequential therapy with activated prothrombin complex concentrate and recombinant factor VIIa in patients with severe haemophilia and inhibitors.
10,11) Avail able replacement options include FFP, plasma derived factor VII concentrates, prothrombin complex concentrates and recombinant-activated factor VII (rFVIIa).
The report analyzes the markets for factor XIII concentrates, fibrinogen concentrates, albumins, antithrombins and prothrombin complex concentrates in the US, the top five countries of Europe (the UK, Germany, France, Italy and Spain), and Japan.

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