proteosome


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pro·te·o·some

(prō'tē-ō-sōm),
A cluster of genes that encode components of the cell cytosolic proteolytic complex, a set of proteins thought to be involved in cellular processing and transport of peptides in the formation of the major histocompatibility complex class I molecules.
[proteo- + G. sōma, body]

pro·te·o·some

(prō'tē-ō-sōm)
A cluster of genes that encode components of the cell cytosolic proteolytic complex, a set of proteins thought to be involved in cellular processing and transport of peptides in the formation of the major histocompatibility complex class I molecules.
[proteo- + G. sōma, body]

proteosome

(prōt′ē-ŏ-sōm″)
An intracellular enzyme that degrades misfolded or damaged proteins and modulates the quantity of regulatory proteins in the cell. The breakdown of proteins by proteosomes (proteolysis) is triggered when damaged proteins are tagged by ubiquitin.
References in periodicals archive ?
Other combinations currently under investigation include combining MP with the proteosome inhibitors.
The company notes that allowance of this patent further enhances the strategic development of a broad intellectual property estate surrounding patented core technology based upon vaccine formulations comprising Proteosome adjuvant/delivery technologies.
ID Biomedical is a North American based biotechnology company focused on the development of proprietary subunit vaccine products, including those based on its Proteosome platform intranasal adjuvant/delivery technology.
Combination studies with GX15-070 demonstrated that it enhanced the anti-myeloma activity stimulated by melphalan, dexamethasone, and bortezomib, a proteosome inhibitor.
The phosphorylated PTEN (p-PTEN) is less susceptible to degradation by the proteosome but is less active.
Our Proteosome technology, which was initially invented at the Walter Reed Army Institute of Research, has been specifically designed to create nasal vaccines that elicit protective immune responses at the mucosal surfaces which line the respiratory tract including the nose, throat and lungs.
Gemin X announced today the initiation of a Phase 1/2 clinical trial of GX15-070 in combination with docetaxel (Taxotere[R]), a chemotherapeutic agent, in patients with non-small cell lung cancer (NSCLC), and a Phase 1 trial in combination with bortezomib (Velcade[R]), a proteosome inhibitor, in patients with mantle cell lymphoma (MCL).
This is a signal in the cells for proteins such as HIF-1 a transcription factor that is constitutively expressed in the cells, but is continously degraded by ubiquitinization in the proteosomes.
What is the role of proteosomes, which remove no longer needed and even dangerous proteins (such as E2F in S phase)?
The flu vaccine is created by combining Proteosomes with a purified preparation of influenza proteins that includes the hemagglutinin protein.