Aside from water, which comprises 70-80% of human cartilage, collagen and proteoglycans
are its major components, each assuming 10-20% of the avascular glossy covering of the underlying subchondral bone, followed by the chondrocytes, which produce and maintain the cartilage ECM and comprise 1-5% of it.
For example, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) identifies areas of decreased cartilage proteoglycan
Pathogenesis of diabetic vascular disease: evidence for the role of reduced heparan sulfate proteoglycan
2005) and has shown alteration in its expression pattern in response to other syndecan isoforms or other heparan sulfate proteoglycans
as embryogenesis proceeds.
Effects of beta-xylosides on proteoglycan
biosynthesis and morphology of PC12 pheochromocytoma cells and primary cultures of rat cerebellum.
Heparan sulfate proteoglycan
binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread.
Two sequence-specific peptide antisera (LF-15 and LF-30) generated against synthetic peptides corresponding to amino acids 11-24 and 5-17 of the human core proteins of 2 small leucine-rich proteoglycans
, biglycan and decorin, were used to characterize territorial or interterritorial cartilage matrices.
Campylobacter bound to proteoglycans
within 2 minutes after being exposed to the mixture, Mandrell says.
They have been able to clone several types of proteoglycans
, and they're trying to find out which one plays the most significant role.
Dermaplant Dermal Allograft, composed of collagen fibers, proteoglycans
, and an elastic network, can be used in the repair or replacement of inadequate or damaged soft tissue.
After electrophoretic separation of protein bands, a portion of the slab was removed and stained for acidic proteoglycans
with Alcian blue.
Recently, for example, a team of scientists reported that it had used the AFM to measure the binding strength of cell adhesion proteoglycans
(molecules containing a mixture of proteins and sugars) from a marine sponge.