Xu, "Protein splicing
involving the Saccharomyces cerevisiae VMA intein: the steps in the splicing pathway, side reactions leading to protein cleavage, and establishment of an in vitro splicing system," The Journal of Biological Chemistry, vol.
Krainer, "A rational nomenclature for serine/arginine-rich protein splicing
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Myotonic dystrophy type 1 involves a type of RNA defect known as a "triplet repeat," a series of three nucleotides repeated more times than normal in an individual's genetic code, resulting in a number of protein splicing
Boston Biomedical Research Institute (Watertown, MA) has patented compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing
and especially relates to the inhibition of protein autosplicing of intein-containing proteins.
Since 1990, biologists have observed this bizarre phenomenon, called protein splicing, in about 100 proteins in some 30 single-celled organisms throughout nature.
Perler of New England Biolabs in Beverly, Mass., a pioneer in protein splicing.
Since the researchers reported this proof that protein splicing happens, investigators have worked to describe the steps by which an intein cleaves the chemical bonds that hold it within the precursor protein and then seamlessly joins the protein fragments from which it has escaped.
"What we still have to discover is how protein splicing is controlled.