The specific antisense significantly decreased the overexpression of a substance called amyloid beta protein precursor
, which normalized the amount of amyloid beta protein in the body.
Levels of amyloid-[beta] protein precursor
(A[beta]PP) [beta]-carboxyterminal fragments were decreased.
Protein name 6 78 kDa glucose-regulated protein precursor
(GRP 78) 7 Protein disulfide-isomerase precursor (EC 5.
Of the 18 differentially displayed proteins, 12 proteins (a-1B-glycoprotein, keratin type II, neurofilament triplet L protein, vitamin D-binding protein precursor
, protease C1 inhibitor precursor, keratin type I cytoskeleton, complement factor B, complement C1r subcomponent precursor, transthyretin precursor, zinc finger protein 792, kininogen-1 precursor, and PRAME family member 7) decreased in concentration after TCC exercise; 4 proteins (complement factor H, apolipoprotein C-III precursor, complement C3 precursor, and [[alpha].
What's more, bacteria use a protein precursor
of L-lysine to construct their cell walls.
16-21] Among localized (or predominantly localized) forms, amyloid derived from A[Beta] protein precursor (A[Beta]PP) and prion protein (PrP) are associated with cerebral pathologic conditions, such as Alzheimer disease (AD), aging, familial cerebral amyloidosis (prototype Dutch), and spongi-form encephalopathies.
Outside the central nervous system, many cells and tissues contain A[Beta] protein precursor isoforms.
The monoclonal antibody assay measures CSF levels of soluble APP, a substance produced during the body's normal processing of amyloid beta protein precursor
Compugen has identified an alternative splicing event in the gene that codes for the protein precursor
of two natriuretic peptide hormones: atrial natriuretic peptide (ANP) and Urodilatin.
They added to the mice a gene for the protein precursor
of beta-amyloid, having first given the gene a mutation identical to one found in a family plagued by early-onset Alzheimer's.
injected eight healthy human volunteers with gp 160, the protein precursor
to gp 120 and another AIDS protein known as gp41.
11 NATURE that a newly discovered protein precursor
for Alzheimer-associated amyloid also contains a structure similar to known inhibitors of certain enzymes.