protein phosphatases


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pro·tein phos·pha·tas·es

a class of enzymes that catalyze the dephosphorylation of specific phosphorylated proteins.
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There was a C-terminal repeat part which was a representative point of protein phosphatases.
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.
Arabidopsis ABA response gene ABI1: features of a calcium-modulated protein phosphatase.
Studies have shown that phytotoxicity of microcystins interferes with metabolism and biomass of aquatic and terrestrial plants, causin reduction of protein phosphatases 1 and 2A, oxidative stress, decrease in photosynthetic activity and even apoptosis.
Calcineurin (Cn) [3], a heterodimeric serine/threonine phosphatase enzyme, is the only protein phosphatase dependent on [Ca.
To summarize, the main core of kinases and phosphatases includes CaMKII, PKA, protein phosphatase 1 (PP1), and protein phosphatase 2b (PP2b, calcineurin) (Fig.
The molecular basis of the tumor-promoting ability of microcystin-LR is unclear but most likely involves protein phosphatase inhibition leading to hyperphosphorylation of many cellular proteins and, consequently, destruction of cell-cycle control (Fujiki and Suganuma 1999; Guy et al.
Conversely, protein phosphatase 1 and glucocorticoids are neurophysiological phenomena that limit what can be learned and cause forgetfulness.
Both isoenzyme couples possess phosphotyrosine protein phosphatase activity also.
Calyculin-A, an inhibitor for protein phosphatases, induces cortical contraction in unfertilized sea urchin eggs.
Similarly, okadaic acid from marine microalgae has been employed as a specific inhibitor of protein phosphatases 1 and 2a.

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