protein kinase


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to protein kinase: Protein kinase C, Protein kinase B

protein kinase

n.
Any of a group of kinases that phosphorylate the amino acids serine, threonine, and tyrosine in certain proteins, that regulate essential aspects of cell growth and movement, and that can cause cancer and other diseases when dysfunctional.

protein kinase

This name was officially retired in 2005; however, although the term is nonspecific, it is still in common use. It is now formally divided into:
• EC 2.7.11.1, non-specific serine/threonine protein kinase;
• EC 2.7.11.8, Fas-activated serine/threonine kinase;
• EC 2.7.11.9, Goodpasture antigen-binding protein kinase;
• EC 2.7.11.10, IκB kinase;
• EC 2.7.11.11, cAMP-dependent protein kinase;
• EC 2.7.11.12, cGMP-dependent protein kinase;
• EC 2.7.1.13, protein kinase C;
• EC 2.7.11.21, polo kinase;
• EC 2.7.11.22, cyclin-dependent kinase;
• EC 2.7.11.24, mitogen-activated protein kinase;
• EC 2.7.11.25, mitogen-activated protein kinase kinase kinase;
• EC 2.7.11.30, receptor protein serine/threonine kinase; and
• EC 2.7.12.1, dual-specificity kinase.

protein kinase

an ENZYME that catalyses the transfer of a phosphate group from ATP to an AMINO ACID in a PROTEIN. In this way, the activity of enzymes can be decreased or increased. By thus altering proteins, kinases are thought to be important in mediating various processes in the CELL.
References in periodicals archive ?
5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors.
Schulman, "Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function," Annual Review of Biochemistry, vol.
Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells.
Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I.
Caplan, "AMP-activated protein kinase regulates the assembly of epithelial tight junctions," Proceedings of the National Academy of Sciences of the United States of America, vol.
Feng et al., "Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver," Journal of Lipid Research, vol.
Levine, "Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the e isozyme of protein kinase C," Journal of Neuroscience, vol.
Atypical PKCs (including protein kinase [zeta] and [iota]/[lambda] isoforms), which belong to the PKC family, require neither calcium nor diacylglycerol for activation.
Zhu et al., "Phosphatidylinositol 3kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites," Journal of Biological Chemistry, vol.
AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
However, under oxidizing conditions, the increased level of intracellular ROS promotes the dissociation of Nrf2 and Keap1, either by the oxidization of key reactive cysteine residues (Cys273, Cys288, and Cys151) that govern Keap1 activity or via the activation of kinases, such as protein kinase C (PKC), MAPK, phosphatidylinositide 3-kinases (PI3Ks), and protein kinase-like endoplasmic reticulum kinase (PERK) that phosphorylate Nrf2 [79-81].
The predicted RPG5 protein has a N-terminal nucleotide-binding site (NBS), leucine rich repeats (LRR) and C-terminal protein kinase domain.

Full browser ?