Prostate specific antigen

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A gene on chromosome 19q13.41 that encodes a serine protease with diverse physiological functions, which may also have a role in carcinogenesis. KLK3 hydrolyses semenogelin-1, leading to the liquefaction of the seminal coagulum.

PSA (Prostate specific antigen)

A tumor marker associated with prostate cancer.
Mentioned in: Tumor Markers

Patient discussion about Prostate specific antigen

Q. Would kidney stones affect a PSA reading? Would drinking lots of grapefruit juice affect a PSA reading? My husband's PSA reading jumped from a 4.2 to a 17 in @ 2 years' time. How can that be? This man takes all sorts of supplements and really watches his diet. He also takes good care of his body, and does NOT look or act 68.

A. You should get your parathyroid gland checked out. Your calcium level might be causing the kidney stones.

Q. Rising PSA to 10 with two negative biospies? Expect cancer? 67 yrs old in good health otherwise.

A. High values don't always mean it's cancer. At 67 years old, you're prostate is most likely enlarging, resulting in the higher PSA results. And after two negative biopsies, it sounds like you're in the clear. Like Brandon said though, keep up with your regular check ups.

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References in periodicals archive ?
Use of the percentage of free prostatic specific antigen to enhance differentiation of prostate cancer from benign prostate disease.
Evaluation of percentage of free prostatic specific antigen to improve specificity of prostate cancer screening.
Prospective use of free prostatic specific antigen to avoid repeat prostate biopsies.
The ratio of free to total serum prostatic specific antigen and its use in differential diagnosis of prostate carcinoma in Japan.
Measurement of the proportion of free to total prostatic specific antigen improves diagnostic performance.
Early detection of residual prostate cancer after radical prostatectomy by an ultrasensitive assay for prostatic specific antigen.
Ultrasensitive time-resolved immunofluorometric assay of prostatic specific antigen.
Clinical application of ultrasensitive prostatic specific antigen Assays.