prostatic intraepithelial neoplasia


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pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a (PIN),

dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with cell crowding, variation in nuclear size and shape, and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with cell crowding, nucleomegaly and nucleolomegaly, and irregular cell spacing.

pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a

(PIN) (pros-tat'ik in-tra-ep'i-thē'lē-ăl nē'ō-plā'zē-ă)
Dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with variation in nuclear size and shape and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with nucleomegaly, nucleolomegaly, and irregular cell spacing.
References in periodicals archive ?
Whereas high-grade prostatic intraepithelial neoplasia, urothelial carcinoma in situ, and germ cell neoplasia in situ are all discussed in the recent WHO publication on tumors of the genitourinary system, not a single mention is made of any lesion being premalignant in the kidney.
Hwang, "Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia," The Journal of Pathology, vol.
The significance of a typical adenomatous hyperplasia and prostatic intraepithelial neoplasia for the development of prostate carcinoma.
The relationship between prostatic intraepithelial neoplasia and prostate cancer: critical issues.
High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases.
The term Paneth cell-like change has been used to describe distinctive eosinophilic neuroendocrine cells that can be seen in benign prostate glands, high-grade prostatic intraepithelial neoplasia, intraductal carcinoma, and usual acinar adenocarcinoma of the prostate (Figure 3, B).
Two critical histological diagnoses that are predictive of an underlying prostatic adenocarcinoma are atypical small acinar proliferations (ASAP), also referred to as ATYP, and high-grade prostatic intraepithelial neoplasia (HGPIN).
High-grade prostatic intraepithelial neoplasia (PIN) represents a first step in the change from normal to cancerous prostate cells.
Screening/early detection; no known prostate cancer or prostatic intraepithelial neoplasia (PIN)
Washington, April 27 (ANI): A new study, conducted by Canadian researchers, has found that the combination therapy of vitamin E, selenium and soy does not prevent the progression from high-grade prostatic intraepithelial neoplasia (HGPIN) to prostate cancer.
An extract of the catechins found in green tea appears to be effective in preventing the progression of high-grade prostatic intraepithelial neoplasia to invasive prostate cancer, Saverio Bettuzzi, Ph.