Prostatic intraepithelial neoplasia (PIN) is broadly characterized by the growth of cytologically atypical cells within architecturally benign
prostatic ducts or acini and is classified as either low or high grade (LGPIN or HGPIN).
Periurethral
prostatic ducts are particularly susceptible to estrogen-driven cancers (Bosland et al.
41] ZhouZ, Flesken-Nikitin A, Nikitin AY Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of
prostatic ducts.
3) Ductal tumors mainly arise from primary periurethral
prostatic ducts whereas acinar tumors arise from other periurethral
prostatic ducts.
Small cell carcinoma of the prostate is believed to originate from epithelial cells of
prostatic ducts and acini, as well as the endothelium of the prostatic urethra.
Non-specific granulomatous prostatitis and xanthogranulomatous prostatitis are likely caused by a blockage of
prostatic ducts and stasis of gland secretions.
Spread of adenocarcinoma within
prostatic ducts and acini: morphologic and clinical correlations.
10] Typically, entry of microorganisms occurs via the urethra into the
prostatic ducts due to direct migration or with intraprostatic reflux of urine.
3) Additionally, invasive prostatic acinar adenocarcinoma, prostatic ductal adenocarcinoma, and urothelial carcinoma involving
prostatic ducts mimic IDC-P morphologically.
3] Originally, ductal carcinoma of the prostate was thought to have arisen from the prostatic utricle in the form of a mullerian ductal structure; however, immunohistochemistry studies have since shown that this rare form of prostate cancer arises from the
prostatic ducts themselves.
The two main techniques are (1) removal of the prostatic adenoma using the technique of a Millen simple retropubic prostatectomy, excising the adenoma tissue containing the
prostatic ducts and most acini, leaving the surgical capsule and seminal vesicles intact,[sup.
