First, we histologically examined all prostate lobes and the periurethral
prostatic ducts for pathologic lesions in two cohorts of rats, one exposed continuously from implantation through adulthood and the other developmentally exposed from implantation through PND 21, the "stop-dose" BPA cohort.
Histologic analysis revealed adenomatous and fibromuscular stromal hyperplasia with chronic active inflammatory changes, squamous metaplasia of
prostatic ducts, bland infarction and reactive glandular and stromal atypia.
(16) More recently, the definition of IDC-P is more restricted to the proliferation of malignant prostatic secretory epithelial cells within preexisting
prostatic ducts and acini, with complex architectural pattern (solid/cribriform) and/or displaying significant cytologic atypia; thus, by definition, IDC-P retains the basal cell layer and can be distinguished from invasive cribriform adenocarcinoma with immunohistochemical stains for basal cell markers (p63, CK5/6, or CK903) (Figure 3, C and D).
Because TCC in situ of the bladder frequently shows pagetoid spread,
prostatic ducts involved by TCC frequently have a basal cell layer as in HGPIN.
In diabetic rats (D), walls of
prostatic ducts were thin and undulated (Figures 1(b), 1(d), 2(D), and 3(D)); relatively thicker ductal walls were seen in diabetic treated groups (Figures 3(DZ), 3(DR), 3(DG), 4(DZ), 4(DR), and 4(DG)).
[41] ZhouZ, Flesken-Nikitin A, Nikitin AY Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of
prostatic ducts. Cancer Res.
(3) Ductal tumors mainly arise from primary periurethral
prostatic ducts whereas acinar tumors arise from other periurethral
prostatic ducts.
Small cell carcinoma of the prostate is believed to originate from epithelial cells of
prostatic ducts and acini, as well as the endothelium of the prostatic urethra.
Non-specific granulomatous prostatitis and xanthogranulomatous prostatitis are likely caused by a blockage of
prostatic ducts and stasis of gland secretions.
Prostatic intraepithelial neoplasia (PIN) is broadly characterized by the growth of cytologically atypical cells within architecturally benign
prostatic ducts or acini and is classified as either low or high grade (LGPIN or HGPIN).
Periurethral
prostatic ducts are particularly susceptible to estrogen-driven cancers (Bosland et al.
These risk factors include benign prostatic hyperplasia, frequent sexual activity, prolonged sexual abstinence, sexually transmitted infections, HIV trauma, stress or transrectal prostate biopsy.[sup.5,6,8]-[sup.10] Typically, entry of microorganisms occurs via the urethra into the
prostatic ducts due to direct migration or with intraprostatic reflux of urine.[sup.11,12] Usual therapy is broad spectrum antibiotics for 6 weeks; however, in this case, a longer duration was advised.[sup.5,11]-[sup.13] Acute bacterial prostatitis is most often associated with E.
