Prostate specific antigen

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Related to Prostate specific antigen: Prostate Enlargement


A gene on chromosome 19q13.41 that encodes a serine protease with diverse physiological functions, which may also have a role in carcinogenesis. KLK3 hydrolyses semenogelin-1, leading to the liquefaction of the seminal coagulum.

PSA (Prostate specific antigen)

A tumor marker associated with prostate cancer.
Mentioned in: Tumor Markers

Patient discussion about Prostate specific antigen

Q. Would kidney stones affect a PSA reading? Would drinking lots of grapefruit juice affect a PSA reading? My husband's PSA reading jumped from a 4.2 to a 17 in @ 2 years' time. How can that be? This man takes all sorts of supplements and really watches his diet. He also takes good care of his body, and does NOT look or act 68.

A. You should get your parathyroid gland checked out. Your calcium level might be causing the kidney stones.

Q. Rising PSA to 10 with two negative biospies? Expect cancer? 67 yrs old in good health otherwise.

A. High values don't always mean it's cancer. At 67 years old, you're prostate is most likely enlarging, resulting in the higher PSA results. And after two negative biopsies, it sounds like you're in the clear. Like Brandon said though, keep up with your regular check ups.

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References in periodicals archive ?
Free and total prostate specific antigen in benign prostatic hyperplasia and prostate cancer.
Histopathological study of transrectal ultrasound guided biopsies of prostate in patients with raised serum prostate specific antigen.
Prostate specific antigen was done in 07 patients who were suspected to have malignancy but it was below 10 ng/dl and therefore they were included in the study.
The use of prostate specific antigen and prostate specific antigen density in the diagnosis of prostate cancer in a community based urology practice.
Combination of Prostate Specific Antigen, Clinical stage and Gleason grade to predict Pathological stage of prostate cancer--a multi institutional update.
Diagnosis of prostatic carcinoma; the yield of serum prostate specific antigen, digital rectal examination and transrectal ultrasonography.
RE: A prospective study to evaluate the role of complexed prostate specific antigen and free/total prostate specific antigen ratio for the diagnosis of prostate cancer [Letter].
Of the 12 patients that were evaluable for antitumor activity, 8 patients (67%) experienced a confirmed decline in prostate specific antigen (PSA) levels of greater than 50% and 6 patients (50%) experienced PSA declines of greater than 90%.
The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3.
The current test for diagnosis of prostate cancer by elevated prostate specific antigen (PSA) in blood of men middle-aged and older is estimated to be only about 30% specific and thus gives a substantial number of false-positive results.

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