Prostaglandins


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prostaglandins

A group of unsaturated fatty acid mediators occurring throughout the tissues and body fluids. They are generated from cell membrane ARACHIDONIC ACID by the action of phospholipase A2 and function as hormones. They have many different actions. They cause constriction or widening of arteries, they stimulate pain nerve endings, they promote or inhibit aggregation of blood PLATELETS and hence influence blood clotting, they induce abortion, reduce stomach acid secretion and relieve asthma. They can both stimulate and inhibit immune responses. Some painkilling drugs, such as aspirin, act by preventing the release of prostaglandins from injured tissue.

prostaglandins

a group of lipid substances that exert a wide range of stimulatory effects on the body, the most important of which is the enhancement of the effects of CYCLIC AMP. Prostaglandins are derived from many tissues including the prostate gland (or can be made synthetically), and have been used in the induction of labour and abortion.

Prostaglandins

Prostaglandins are produced by the body and are responsible for inflammation features, such as swelling, pain, stiffness, redness and warmth.
References in periodicals archive ?
Pain and inflammation occur in arthritic dogs because of complicated chemical pathways that result in prostaglandin synthesis.
An investigation into the role of prostaglandins in zebrafish oocyte maturation and ovulation.
Prostaglandin E (PGE) is a metabolite of the arachidonic acid produced by the cyclooxygenase enzyme, which is known to prevent inflammation developed in the airways [7].
A previous study found that maternal exposure to indomethacin, an analgesic with a similar mechanism of action to ibuprofen, blocked prostaglandin signaling in fetal rat testicular tissue.
It seems that the intraocular manipulations during cataract surgery cause breakdown of the blood-aqueous barrier promoting an inflammatory cascade with the release of prostaglandins by ciliary body [12-15].
In second-trimester abortions induced with prostaglandins, if the cervix is not yielding despite good uterine contractions, there is an option to withhold further doses to avoid cervical injuries.
IBUPROFEN: A COX inhibitor blocking the production of several types of prostaglandins, which cause inflammation and pain.
The most common treatments for primary dysmenorrhea in conventional medicine are nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, which inhibit the formation of prostaglandins; oral contraceptives; and intrauterine devices (IUDs), which thin the endometrial lining and reduce the amount of prostaglandins being produced.
Foley catheter balloon vs locally applied prostaglandins for cervical ripening and labor induction: a systematic review and metaanalysis.
In addition, during inflammation, other proinflammatory prostaglandins as PGE2 and TXA2 might also be produced in excess after UUO.
All the three prostaglandins were found to have nearly equal efficacy.
Patients received induction in the form of prostaglandins. The dose of prostaglandins was one tablet 3mg placed in posterior fornix of vagina, which was repeated 6 hours later if labour did not start caesarean section was performed if induction failed after a period of six hours.