Prospect Hill Virus

A serologically distinct member of the Hantavirus group isolated from meadow voles (Microtus pennsylvanicus), a rodent reservoir, which is not thought to infect humans
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Cao Bang virus (CBNV TC-3), EF543526; Hantaan virus (HTNV 76-118), NC_005219; Seoul virus (SEOV 80-39), NC_005237; Soochong virus (SOOV SC-1), AY675353; Dobrava virus (DOBV Greece), NC_005234; Puumala virus (PUUV Sotkamo), NC_005223; Prospect Hill virus (PHV PH-1), X55129; Tula virus (TULV Moravia 5302v), NC_005228; Sin Nombre virus (SNV NMH10), NC_005215, and Andes virus (ANDV Chile-9717869), NC_003467.
In 1982 the Prospect Hill virus was isolated in Frederick, Md, and cases of infected rodents were reported from numerous cities throughout the United States.
These include Prospect Hill virus associated with the meadow vole, Microtus pennsylvanicus (Lee et al, 1982), Isla Vista virus, associated with the California vole, M.
Although hantaviruses from North American arvicoline rodents have never been associated with human disease, antibodies reactive with Prospect Hill virus have been documented in American mammalogists, who have had extensive exposure to meadow voles (Tsal et al.
Adequate serum specimens were available for antibody testing in 39 of the 42 confirmed case-patients; 38 had detectable antibodies against heterologous hantavirus antigens, particularly Prospect Hill virus.
More than 20 years ago, when Prospect Hill virus was discovered in meadow voles (Microtus pennsylvanicus) captured in Frederick, Maryland, USA, serologic evidence suggestive of hantavirus infection was found in the northern short-tailed shrew (Blarina brevicauda) (4).
At CDC, purified recombinant N protein has been used as an antigen for IgG enzyme-linked immunosorbent assays (ELISAs) Mat demonstrated higher specific optical density values compared to Prospect Hill virus, the viral antigen previously identified as most reactive with serum specimens obtained from patients and rodents in the southwestern United States.
Hantaan virus (HTNV) shares a multimillennium relationship with the striped field mouse (Apodemus agrarius), Dobrava virus (DOBV) with the yellow-necked field mouse (Apodemus flavicollis), Seoul virus (SEOV) with the Norway rat (Rattus norvegicus), Thailand virus (THAIV) with the bandicoot rat (Bandicota indica), Puumala virus (PUUV) with the bank vole (Myodes glareolus, formerly Clethrionomys glareolus), Tula virus (TULV) with the European common vole (Microtus arvalis), Prospect Hill virus (PHV) with the meadow vole (M.
Polymerase chain reaction (PCR) evidence of hantavirus infection was found in lung tissue, and nucleotide sequence analysis of viral genetic material PCR-amplified from the lung suggests the presence of a previously unrecognized hantavirus most closely related to but distinct from both the Prospect Hill virus and the virus circulating in the four-corners area.
Previously, two well-characterized hantaviruses had been isolated from different species in the United States: Seoul virus from Rattus norvegicus (Norway rat) and Prospect Hill virus from Microtus pennsylvanicus (meadow vole) (5).
Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA.
Prospect Hill virus, an indigenous North American hantavirus, was isolated from the meadow vole (Microtus pennsylvanicus) as early as 1982 (11) but has never been associated with human disease.