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Related to Proscar: Avodart


Propecia, Proscar

Pharmacologic class: Androgen inhibitor

Therapeutic class: Sex hormone, hair regrowth stimulant

Pregnancy risk category X


Suppresses dihydrotestosterone levels by inhibiting the hepatic enzyme 5-alpha reductase, which converts testosterone to dihydrotestosterone in prostate, liver, and skin


Tablets: 1 mg (Propecia), 5 mg (Proscar)

Indications and dosages

Symptomatic benign prostatic hypertrophy (BPH)

Adults: 5 mg P.O. daily

To reduce risk of progression of BPH symptoms

Adults: 5 mg P.O. daily (Proscar) given with doxazosin

Male-pattern baldness

Adults: 1 mg P.O. daily

Off-label uses

• Acne in women

• Hirsutism


• Hypersensitivity to drug or its components

• Pregnant patients, women who may potentially be pregnant


Use cautiously in:

• hepatic impairment, obstructive uropathy, increased risk of high-grade prostate cancer, decrease in serum prostate-specific antigen (PSA) level

• women (not indicated)

• children (not indicated).


• Give with or without food.

• Know that female patients who are or may be pregnant shouldn't handle crushed or broken tablets. (Tablets are coated, so handling of intact tablets doesn't pose a problem.)

Adverse reactions

CNS: dizziness, headache, asthenia

EENT: lip swelling

GU: erectile dysfunction, decreased ejaculate volume, decreased libido, testicular pain, gynecomastia

Musculoskeletal: back pain

Skin: rash


Drug-drug. Theophylline: increased theophylline clearance

Drug-diagnostic tests. PSA: 50% decrease

Patient monitoring

• Carefully evaluate sustained PSA increases during therapy.

• Monitor fluid intake and output closely.

Patient teaching

• Tell patient he may take drug with or without food.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Inform patient that he may experience erectile dysfunction and decreased ejaculate. Advise him to discuss these issues with prescriber.

• Caution female caregiver or companion who is or may be pregnant not to handle crushed or broken tablets.

• Tell patient he may need at least 6 months of therapy for BPH treatment and at least 3 months to see improvement in male-pattern baldness.

• Inform patient with BPH that he'll undergo periodic digital rectal exams.

• Instruct patient not to donate blood for at least 1 month after last dose.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug finasteride.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Finasteride, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A brand name for FINASTERIDE.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The men were randomly given a fixed combination of saw palmetto extract and stinging nettle root or the 5-alpha-reductase inhibitor Proscar (finasteride).
Both Propecia and Proscar are manufactured by Merck.
comparison of Finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers.
(9) And, it has been shown that the anti-BPH activity of SPE is comparable with the commonly used 5[alpha]-reductase inhibitor, Finasteride (Proscar), although it is still uncertain whether the inhibition of 5[alpha]-reductase is the sole mechanism of action of SPE.
Drugs known as 5-alpha-reductase inhibitors like finasteride (Proscar) are widely used to treat benign prostatic hyperplasia (enlarged prostate).
of Montana) explains why Proscar (finasteride) was deemed too risky despite a promising clinical trial.
* Finasteride (Proscar) acts on the male hormone (testosterone) to shrink the prostate.
The herb saw palmetto has a pretty good track record in improving symptoms of enlarged prostate, with an analysis of 21 clinical trials involving more than 3,000 men finding it worked about as well as the most widely prescribed medication, finasteride (Proscar).
The following are promising candidates: 5-alpha reductase inhibitors (Proscar), soy and phytoestrogens, retinoids, vitamins E and D, selenium, and nonsteroidal anti-inflammatories, or NSAIDS.
Medications like dutasteride (Avodart) and finasteride (Proscar) may help to reduce prostate size without surgery, but they generally take several months to work.
Harkaway in an interview, since an enlarged prostate should lead one to consider prescribing a 5-alpha reductase inhibitor such as finasteride (Proscar) or dutasteride (Avodart).