Fermentation of Propionibacterium acnes
, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus .
Pathological mechanisms of acne with special emphasis on Propionibacterium acnes
and related therapy.
Many factors including androgenic stimulation, Propionibacterium acnes
activity, sebum production, hypercornification, as well as inflammatory mediator responses are thought to play a role in acne pathogenesis.
Biofilm formation by Propionibacterium acnes
on biomaterials in vitro and in vivo: impact on diagnosis and treatment.
Caption: Propionibacterium acnes
is shown under magnification.
Objective: Follicular hyperkeratinization and Propionibacterium acnes
colonization are mainly responsible for the pathogenesis of acne.
The pathogenesis of acne vulgaris is known to be multimodal, including ductal hypercor-nification, enhanced sebaceous gland activity, colonization by Propionibacterium acnes
The four major factors that are primarily involved in the pathogenesis of acne include increased sebum production, hypercornification of the pilosebaceous duct, abnormal colonization by propionibacterium acnes
The British Association of Dermatologists conference heard over-prescribing could cause the emergence of antibiotic-resistant Propionibacterium acnes
29) The development of acne is characterized by the excessive production and oxidation of sebum--the skin's natural oil--that generates inflammation and is a breeding ground for bacteria called Propionibacterium acnes
Acne begins with abnormal keratinization and a complex interplay between sebum production, hypersensitivity to androgen stimulation, changes in lipid compound, Propionibacterium acnes
, and local inflammatory cytokines elaborated by the innate immune system.
The antibiotic angle makes total sense: You have bacteria, Propionibacterium acnes
, playing what is thought to be a causative role in the pathogenesis of acne; you kill that bacteria; the acne improves.