Sanders, "Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine
, and ethylenediaminetetraacetic acid," Hepatology, vol.
As corneal, left CL and left storage case cultures revealed positive PCR test for Acanthamoeba, hourly chlorhexidine (0.2 mg/ml) and propamidine isethionate (1 mg/ml) drops were added to the aforementioned regimen.
Because these recent findings were thought to have occurred secondary to extensive use of the fortified antibiotics including chlorhexidine and propamidine, they were decreased to QID.
Treatment: Topical fumagillin, propamidine
isethionate and oral itraconazole or albendazole.
Biguanides (polyhexidine biguanides, PHMB 0.02%-0.06%, and chlorhexidine 0.02%-0.2%) and diamidines (propamidine
Isethionate 0.1%, Brolene, May and Baker, UK and hexamidine 0.1%, Desmomedine, Chauvin, France) are the most effective cystocidal agents.
Results of a Trial of combined propamidine isethionate and neomycin therapy for Acanthamoeba keratitis.
Successful medical therapy of acanthamoeba keratitis with topical chlorhexidine and propamidine. Eye 1997, 10:113-21.
Resistogram typing was performed by disk diffusion against a panel of 6 chemicals and dyes: cadmium acetate (10 mmol/L), sodium arsenate (0.2 [micro]mol/L), ethidium bromide (15 mmol/L), propamidine
isethionate (2% [wt/vol]), mercuric chloride (0.4 [micro]mol/L), and phenylmercuric acetate (5 mmol/L) as previously described (19,20).
These drugs include neomycin sulfate, paromomycin, natamycin, ketoconazole, ciclopirox olamine,  pentamidine isethionate, propamidine
isethionate, stilbamidine isethionate,  amphotericin B, sulfadiazine, sulfisoxazole, sulfamethoxazole, polymyxin B and E,  and clotrimazole.
Two other patients did not respond to therapy with topical antimicrobial agents (neomycin, propamidine
isethionate, amphotericin, sulfacetamide, and trimethoprim/sulfamethoxazole); however, several weeks after therapy was discontinued the symptoms resolved.
The next level of drugs is represented by the diamidines, namely propamidine and dibromopropamidine.
The two drug options available in the UK are propamidine, in the form of P Brolene and P Golden Eye eye drops, and dibromopropamidine, in the form of P Brolene eye ointment and P Golden Eye ointment.