, a pharmaceutical preparation of purified human aiphal-antitrypsin, blocks endotoxin mediated cytokine release.
(Alpha(1)-Proteinase Inhibitor [Human]) is derived from human plasma and is administered intravenously to raise the levels of A1PI in the blood and lungs.
is not indicated for use in patients other than those with the a specific genetic phenotype.
Talecris developed and manufactures Prolastin
(Alpha1-Proteinase Inhibitor [Human]), a leading treatment for alpha1-antitrypsin deficiency.
Scientists at Cardiff-based BBI will work with the Talecris researchers to develop a tool which will identify patients who may benefit from treatment with the US company's Prolastin
For many years, the only commercially available augmentation therapy was Prolastin
(Bayer), a human [alpha.
Current treatment for AAT deficiency often involves augmentation of the AAT protein itself via intravenous infusion of Prolastin
, which is purified AAT derived from pooled human plasma (Sandhaus 1993, 2001; Stoller et al.
Lioresal baclofen Treatment of intractable Intrathecal spasticity caused by spinal cord injury, multiple sclerosis, other spinal diseases Lupron injection leuprolide acetate Treatment of central Prolastin
alpha-1 -proteinase precocious puberty inhibitor (human) Replacement therapy in the alpha-1 -proteinase inhibitor congenital deficiency state Survanta beractant Prevention and treatment of intratracheal neonatal respiratory suspension distress syndrome.
Stern, commented: "We are pleased to see continued growth in end user demand for both Gamunex, our brand of IGIV, as well as PROLASTIN
, our brand of alpha-1 proteinase inhibitor for the treatment of genetic emphysema, as compared to the first quarter of 2009[.
We were pleased to see higher revenues for Gamunex, our brand of IGIV, as well as Prolastin
, our brand of alpha-1 proteinase inhibitor for the treatment of genetic emphysema, as compared to the 2008 fourth quarter," said Lawrence D.
Plasma-derived AAT therapeutics on the market include Prolastin
(Talecris), Aralast (Baxter) and Zemaira (CSL Behring), and there are a number of recombinant products in development.
-C is indicated for the treatment of panacinar emphysema in patients with alpha1-antitrypsin (AAT) deficiency.