Initially acridine analogs were clinically utilized as antimicrobials and antimalarial agent in early and middle nineteen century in which amino derivatives of acridine mainly acriflavine, trypaflavin, gonoflavin and proflavine
were mostly used, later quinacrine was used as antiseptics in hospitals till the discovery of penicillins as antibiotic agents .
38) reported perioral and mucosal edema caused by contact allergy to proflavine (an antiseptic) in an acriflavine (a proflavine derivative) mouthwash.
Perioral and mucosal oedema due to contact allergy to proflavine.
2) and dressed with D' Mag spray (a) (Topical spray containing Gamma BHC, Proflavine
hemisulphate, Cetrimide with natural oils).
The interaction of polyphospates and cationic dyes such as toludine blue , 4,5,4',5'-dibenzo-3,3'-diethyl-9-methylthiocarbocyanine , acridine orange and proflavine
[7-11] are reported.
To test that hypothesis, Hud and his team selected as their midwife a small molecule called proflavine.
When the researchers added small amounts of proflavine to a test tube containing snippets made up of a few nucleotides, the nucleotides assembled into DNA at a rate 1,000 rimes as fast as that in the absence of proflavine.
Researchers suspect that small molecules like proflavine were widespread on early Earth.
Hud says that he chose to work with proflavine because it has a flat structure that resembles the structure of two nucleotides joined together as they are in DNA's rungs.