prodrug

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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
References in periodicals archive ?
Future strategy to achieve more efficient atenolol prodrugs capable of increasing the liquid formulation stability, eliminating atenolol bitterness, and releasing the parent drug in a programmable manner is (a) synthesis of atenolol prodrugs having p[K.sub.a] around 6 (intestine pH) such as atenolol ProD 3; (ii) in vitro kinetic studies of atenolol ProD 3 performed at pH 6.5 (intestine) and pH 7.4 (blood circulation system); and (iii) in vivo pharmacokinetic studies done in order to determine the bioavailability and the duration of action of the tested prodrug.
Dr Ackerley's main collaborators are Dr Adam Patterson and Dr Jeff Smaill at the Auckland Cancer Society Research Centre, who have played key roles in the development and testing of next-generation prodrugs and imaging molecules.
One unique quality of this d-amphetamine prodrug is there appears to be a limit to the rate at which d-amphetamine is released from LDX.
Phenytoin prodrugs VI: In vivo evaluation of a phosphate ester prodrug of phenytoin after parenteral administration to rats.
Semafore's prodrug technology offers a way to enhance delivery of PI3K inhibitors selectively to the tissues of therapeutic interest while lessening the systemic exposure seen with non-prodrug approaches.
The structure and tumor-selectivity of Super-Leu-Dox is based on a tumor-activated prodrug approach that is similar in concept to Diatos's TSP technology platform.
* Prodrugs themselves may cross-react in immunoassays, thereby confounding pharmacokinetic data and clinical interpretation.
Sweden-based NeuroVive Pharmaceutical has offered exclusive license of a subset of succinate prodrug chemistry under its NVP015 program to BridgeBio Pharma, it was reported yesterday.
The licensed succinate prodrugs have the potential to overcome the disease by bypassing the dysfunctional metabolic pathway, providing an alternate source of energy to the retinal cells.
To overcome the drawbacks of Pt(II)-based complexes, Pt(IV) complexes have been designed and synthesized as prodrugs. Pt(IV) complexes exhibit kinetic inertness and a low-spin [d.sup.6] octahedral geometry, rendering them more stable for oral administration.
The HPC-Ibuprofen conjugates as macromolecular prodrugs were therefore synthesized employing homogenous and one pot reaction methodology using p-toluenesulfonyl chloride.