Future strategy to achieve more efficient atenolol prodrugs
capable of increasing the liquid formulation stability, eliminating atenolol bitterness, and releasing the parent drug in a programmable manner is (a) synthesis of atenolol prodrugs
having p[K.sub.a] around 6 (intestine pH) such as atenolol ProD 3; (ii) in vitro kinetic studies of atenolol ProD 3 performed at pH 6.5 (intestine) and pH 7.4 (blood circulation system); and (iii) in vivo pharmacokinetic studies done in order to determine the bioavailability and the duration of action of the tested prodrug
Dr Ackerley's main collaborators are Dr Adam Patterson and Dr Jeff Smaill at the Auckland Cancer Society Research Centre, who have played key roles in the development and testing of next-generation prodrugs
and imaging molecules.
One unique quality of this d-amphetamine prodrug
is there appears to be a limit to the rate at which d-amphetamine is released from LDX.
VI: In vivo evaluation of a phosphate ester prodrug
of phenytoin after parenteral administration to rats.
technology offers a way to enhance delivery of PI3K inhibitors selectively to the tissues of therapeutic interest while lessening the systemic exposure seen with non-prodrug approaches.
The structure and tumor-selectivity of Super-Leu-Dox is based on a tumor-activated prodrug
approach that is similar in concept to Diatos's TSP technology platform.
themselves may cross-react in immunoassays, thereby confounding pharmacokinetic data and clinical interpretation.
At the site of the tumor, these prodrugs
can be locally activated by tumor-associated proteases.
Sweden-based NeuroVive Pharmaceutical has offered exclusive license of a subset of succinate prodrug
chemistry under its NVP015 program to BridgeBio Pharma, it was reported yesterday.
The licensed succinate prodrugs
have the potential to overcome the disease by bypassing the dysfunctional metabolic pathway, providing an alternate source of energy to the retinal cells.
To overcome the drawbacks of Pt(II)-based complexes, Pt(IV) complexes have been designed and synthesized as prodrugs
. Pt(IV) complexes exhibit kinetic inertness and a low-spin [d.sup.6] octahedral geometry, rendering them more stable for oral administration.
The HPC-Ibuprofen conjugates as macromolecular prodrugs
were therefore synthesized employing homogenous and one pot reaction methodology using p-toluenesulfonyl chloride.