PROC


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PROC

A gene on chromosome 2q13-q14 that encodes a vitamin K-dependent plasma glycoprotein, which is cleaved to its activated form by the thrombin-thrombomodulin complex. Once activated, it degrades activated coagulation factors V and VIII.

Molecular pathology
PROC mutations are linked to thrombophilia due to protein C deficiency, neonatal purpura fulminans and recurrent venous thrombosis.
References in periodicals archive ?
Proc 2005-31 provides a safe harbor for determining the finality of the adoption of a foreign-born child (1) until the Convention is ratified and (2) from a country not a party to the Convention after ratification.