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PROCA gene on chromosome 2q13-q14 that encodes a vitamin K-dependent plasma glycoprotein, which is cleaved to its activated form by the thrombin-thrombomodulin complex. Once activated, it degrades activated coagulation factors V and VIII.
PROC mutations are linked to thrombophilia due to protein C deficiency, neonatal purpura fulminans and recurrent venous thrombosis.