Although the statistical analyses have suggested overall significance of antioxidant therapy in some studies, only those trials using probucol
with or without antioxidant vitamins showed significant effect (Tardif et al.
The most evident biochemical consequence of probucol
treatment thus is a CETP-mediated reduction in HDL-C concentration, which some authors have also attributed in part to inhibition of ATP-binding cassette transporter 1 (ABCA1)-mediated HDL biogenesis.
Pro-atherogenic and anti-atherogenic effects of probucol
and phytosterols in apo E deficient mice: possible mechanisms of action.
The TSAR stent's rough coating enables it to be coated directly with the anti-restenosis drug rapamycin and the antioxidant probucol
promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats.
has antioxidant and anti-inflammatory properties.
Medicamentos antilipemicos dispensados con sus dosis respectivas: a) estatinas (lovastatina, atorvastatina, fluvastatina, pravastatina, simvastatina); b) fibratos (gemfibrozil, bezafibrato, etofibrato, fenofibrato); c) resinas fijadoras de acidos biliares (colestiramina), y d) otros (ezetimibe, probucol
, acido nicotinico).
is a modestly potent LDL-lowering agent with powerful anti-oxidant properties that effectively inhibits the oxidative modification of LDL independent of its lipid lowering effect and also inhibits VCAM-1 and MCP-1 expression and inhibits human aortic SMC proliferation as well as atherogenesis (74).
Succinobucol, a potent lipophilic antioxidant, is the monosuccinic acid ester of probucol
The clinical studies have included short and long-term, placebo-controlled and comparative studies versus statins, fibrates, acipimox and probucol
Ejemplo de esto, el probucol
, un reconocido agente antioxidante, que disminuiria, a dosis bajas, los niveles de transaminasas en pacientes con EHGNA.