proband

(redirected from Probands)
Also found in: Dictionary, Encyclopedia, Wikipedia.

pro·band

(prō'band),
In human genetics, the patient or member of the family that brings a family under study.
Synonym(s): index case
[L. probo, to test, prove]

proband

/pro·band/ (pro´band) an affected person ascertained independently of relatives in a genetic study.

proband

(prō′bănd′, prō-bănd′)

proband

proband

Epidemiology A Pt who triggers study of other members of the family to identify the possible genetic factors involved in a given disease, condition, or characteristic. Cf Index case.

pro·band

(prō'band)
human genetics The patient or member of the family that brings a family under study.
[L. probo, to test, prove]

proband

The presenting patient of a group with an identical or similar disorder, especially the member of a family first found to have an inheritable disorder. Also known as propositus.

proband

an individual considered as the starting point for the study of a family for the inheritance of a particular condition.

proband

propositus.
References in periodicals archive ?
Ordeal-administering priests had a simple solution to the problem of skeptics: Condemn some probands.
Clinical laboratories may offer sequencing of the proband only and/or trio sequencing (analysis of the proband and parents) by WES or WGS.
Methodological differences across studies could certainly be one reason for the inconsistent findings, as studies have generally suffered from small sample size; measures, informants and comparison groups are also different; and the characteristics of the autistic proband were seldom described.
Similar to these reports, our proband was born to consanguineous parents both being carriers of a Robertsonian translocation though no adverse pregnancy outcome was reported in the parents (Figure 1).
Before taking the history, informed consent of parents of proband was taken using the consent form and the information was kept confidential.
Sequencing for both probands and their respective mothers was performed using primers employed for the PCR, with subsequent capillary electrophoresis on the 3130xi Genetic Analyser (Life Technologies, USA).
the subject's family member or close friend) about the proband.
This and the coaching of the probands during the study was performed by a team consisting of a nutritionist, a diabetologist, a physician specialized in nutrition, and an educationalist.
Detection of RB1 mutations in affected families will enhance the quality of clinical management of the probands and relatives at risk (1), (2).