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Compounds or agents capable of generating toxic oxygen species. Compare: antioxidant.
References in periodicals archive ?
Conclusion: Taken together, MAL-A a pro-oxidant compound is likely to be more effective in leukemias, meriting further pharmacological consideration.
The study found that vitamin C killed human ovarian tumor cells in lab dishes by acting as a pro-oxidant, damaging DNA, sabotaging a cellular fuel source called ATP and inhibiting mTOR, a cell growth activator.
NAC exerted a biphasic effect on the intracellular ROS levels depending on incubation time; the antioxidant effect was seen within 2h after NAC treatment, however, a pro-oxidant effect was evident after 48 h treatment.
As by-products of oxygen metabolism, they are regulated by oxidant and antioxidant defense systems, but the imbalance between pro-oxidant and antioxidant defense mechanisms in favor of the pro-oxidant can result in oxidative stress, which can then lead to pathogenesis, e.
A compound such as vitamin C may be able to act both as an antioxidant and a pro-oxidant in chemical reactions, but it is uncertain if the pro-oxidant properties have any biological role.
In a new study, vitamin C was found to kill human ovarian tumor cells in laboratory dishes by acting as a pro-oxidant that damaged deoxyribonucleic acid (DNA) and sabotaged cellular adenosine triphosphate (ATP) and by inhibiting mammalian target of rapamycin (mTOR), a cell growth activator.
Very high levels of antioxidants can cause a harmful pro-oxidant effect.
According to physiological properties of different flavonoids, the flavonols having orto or para hydroxyl group in the 2- phenyl ring are known to have strong antioxidant properties, while free hydroxyl at the 5,7- position proved to have a pro-oxidant effect.
The investigators also observed pro-oxidant properties in solutions containing only intact whey protein, as determined by measuring the rate of liposome peroxidation.
As the activity of glutathione peroxidase, a main scavenger of hydrogen peroxide in gastrointestinal tissue, was significantly decreased in the active and silent group, the misbalance between hydrogen peroxide production and scavenging causes a pro-oxidant shift.
The research by experts at Cardiff University's School of Medicine has discovered that vitamin C can boost heart function by its so-called pro-oxidant effects.