prodrug

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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).
Farlex Partner Medical Dictionary © Farlex 2012

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
TG6002 is a modified Vaccinia virus, with double gene deletion (TK-RR-), and expressing the proprietary FCU1 gene in the cancer cells it has infected, leading to the local conversion of the non-cytotoxic pro-drug, flucytosine, into 5-FU, a widely used cancer chemotherapy.
Although Roberts acknowledged that Frederick's message could be viewed as political, nonsensical and even humorous, the principal was within her rights to see it as a pro-drug message violating school policy.
Pharmacologic ascorbate can act as a pro-drug for hydrogen peroxide (H(2)O(2)) formation, which can lead to extracellular fluid at concentrations as high as 200 [micro]mol/L.
In the case of a pro-drug (one that is administered in an inactive form and must be metabolised in the body to start working), enzyme induction will cause rapid activation and may lead to toxicity.
Copaxone, claims Peptimmune, is a "pro-drug" which makes the demonstration of bioequivalence difficult for a generic copy.
They address platforms and technologies at different stages of clinical and preclinical development, including active targeting, nucleic acid delivery and targeting, intracellular/organelle-specific strategies, pro-drug strategies, organ or tissue-specific drug delivery, drug-polymer conjugates and micelles, and stimuli-responsive systems.
CXL-1020 is a pro-drug that breaks down under physiological conditions and liberates nitroxyl (HNO).
Medical treatment of feline hyperthyroidism has traditionally involved daily use of the azole drugs, methimazole or its pro-drug, carbimazole (many cats require twice daily treatment with these drugs).
Temozolomide is an orally-delivered pro-drug that converts in the body into the same active compound as dacarbazine.
Simeonidis expects INNO-206 to be a very large product as it is a pro-drug to doxorubicin, a common cancer treatment that has sales in hundreds of millions of dollars.
The use of Alvesco (ciclesonide), a pro-drug can reduce oral side-effects due to the pharmacological properties of the agents.