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They found that their monoclonal antibodies reacted to an intermediate, or "oligomer" state of the amyloid and tau proteins seen in Alzheimer's disease, as well as to prion disease proteins.
Other prion diseases include bovine spongiform encephalopathy (mad cow disease) in cattle and Creutzfeldt-Jakob disease in humans.
Human-to-human transmission of prion diseases is of great concern for public health reasons (11-13).
Even so, as a physician I don't fret much about epidemics of prion diseases turning the population into brain-eating zombies.
An easy-to-use diagnostic test would let doctors clearly differentiate prion diseases from other brain maladies.
Humans exposed to contaminated beef products can acquire a human form of BSE, known as vCJD due to its similarities with other human prion diseases.
The ability of [this assay] to detect prions in plasma samples raises the possibility that this assay could be used to improve prion disease diagnosis in humans and animals and to screen the blood supply for prion contamination," wrote Dr.
Covance's neuroscience portfolio offers a wide range of high performing antibodies to key targets in neurodegenerative conditions including Alzheimer's, Parkinson's, and prion diseases.
Krasner (biology, Providence College) gives the background and the real stories behind the development of the Salk polio vaccine and nine other projects to cure, treat or resist such plagues as Chagas Disease, typhus, influenza, smallpox, prion diseases, AIDS, bacterially based ulcers, and Guinea worm disease, as well as the development of the first antibiotics.
Juergen Richt, USDA-ARS Virus and Prion Diseases of Livestock Research Unit, Ames, Iowa; phone (515) 663-7366, e-mail juergen.
It belongs to a group of prion diseases, named for proteins that change into abnormal, infectious clumps that destroy brain cells.
One of the many goals of the Rural Family Health project is to develop a national cohort of farmers and ranchers (men and women) who are willing to participate in a longitudinal study of the impact of prion diseases, such as BSE, on the determinants of health.