Byskov, "Human
primordial germ cells migrate along nerve fibers and Schwann cells from the dorsal hind gut mesentery to the gonadal ridge," Molecular Human Reproduction, vol.
Despite the wide range of applications, very little is known about the mechanisms and miRNAs that govern
primordial germ cell self-renewal and differentiation.
Tapia et al., "Hypoxia induces pluripotency in
primordial germ cells by HIF1alpha stabilization and Oct 4 deregulation," Antioxidants & Redox Signaling, vol.
A vasa-like gene in zebra-fish identifies putative
primordial germ cells. Mech.
(2002) Epigenetic reprogramming in mouse
primordial germ cells. Mech.
Chiquoine, "The identification, origin, and migration of the
primordial germ cells in the mouse embryo," Anatomical Record, vol.
Kessel, "The reciprocal relationship between
primordial germ cells and pluripotent stem cells," Journal of Molecular Medicine, vol.
The localized mRNA includes vasa mRNA, which is a well-known marker of the
primordial germ cells (Schup-bach and Wieschaus, 1986; Fujimura and Takamura, 2000).
Summary: TEHRAN (FNA)- Iranian researchers in collaboration with their Canadian colleagues managed to create early sperm cells, called
primordial germ cells (PGCs), from the skin of individuals, even infertile people.
Towards the use of
primordial germ cells for germline modification.
The factor has a variety of effects on different cell types in vitro, inhibiting the differentiation of embryonic stem cells and promoting the survival and/or proliferation of primitive hematopoietic precursors and
primordial germ cells.
(2007), the migration of the
primordial germ cells starts between the 2nd and 3rd day of incubation, and from the 5th day begins testicular morphogenesis and differentiation of the
primordial germ cells to spermatogonia.
