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PSAProstate-specific antigen. A 34-kD glycoprotein serine protease (formally, kallikrein-related peptidase 3) encoded by KLK3 on chromosome 19q13.41, which has significant homology with other neutral proteases. It is secreted exclusively by the prostate epithelium and is responsible for lysing the seminal coagulum; it is present in the serum and is increased in patients with both benign (acute inflammation and BPH) and malignant (cancer) prostate lesions;. Most serum PSA is bound to protease inhibitors, including alpha1-antichymotrypin (the form usually measured in the lab), alpha1-macroglobulin, and in far lower amounts to alpha1-antitrypsin; small amounts of PSA in the circulation are not bound—i.e., free—to a carrier protein. Prostate cancer is present in 22% of those with PSA levels above 4.0 µg/L, and 60% of those with levels above 10 µg/L.
PSAProstate-specific antigen Urology A 34 kD glycoprotein serine protease with significant homology with other neutral proteases; PSA is secreted exclusively by the prostate epithelium and is responsible for lysing the seminal coagulum; it is present in the serum and is ↑ in Pts with both benign–acute inflammation and BPH and malignant–CA prostate lesions; most serum PSA is bound to protease inhibitors, including α1-antichymotrypin–the form usually measured in the lab, α1-macroglobulin, and in far lower amounts to α1-antitrypsin; small amounts of PSA in the circulation are not bound–ie, free—to a carrier protein; prostate CA is present in 22% of those with PSA levels above 4.0 µg/L, 60% of those with levels above 10 µg/L
PSASee PROSTATE-SPECIFIC ANTIGEN.
PSA (Prostate specific antigen)
Patient discussion about PSA
Q. Would kidney stones affect a PSA reading? Would drinking lots of grapefruit juice affect a PSA reading? My husband's PSA reading jumped from a 4.2 to a 17 in @ 2 years' time. How can that be? This man takes all sorts of supplements and really watches his diet. He also takes good care of his body, and does NOT look or act 68.
Q. Rising PSA to 10 with two negative biospies? Expect cancer? 67 yrs old in good health otherwise.