Misoprostol is the only prostaglandin [E.sub.1] analogue uterine stimulant that is currently commercially available in obstetrics and gynaecology; all other prostaglandin preparations, commercially known as Prostin, Prandin, Prepidil
, and by many other names, are prostaglandin [E.sub.2] analogues, and long preceded the use of misoprostol.
Preinduction cervical ripening with [PGE.sub.2] (Prepidil
Licensed drugs for induction of labour, mostly vaginal prostaglandin gel (Prepidil
) and tablets (Prostin), are expensive and some require refrigeration making them unsuitable for resource-poor settings.
Upon admission, she was given Prepidil
to induce labor.
In a prospective, randomized study of 111 obstetric patients, those who received Cytotec (misoprostol) had a quicker induction of labor, averaging 24 hours from the administration of the drug until delivery, compared with 30 hours in patients who received either Cervidil or Prepidil, Dr.
Nevertheless, Cytotec was associated with a significantly higher incidence of fetal heart tracing abnormalities and contraction abnormalities (50%), compared with Cervidil (14%) and Prepidil (11%), said Dr.
Cervidil and Prepidil are both indicated for cervical ripening.
says that Prepidil
gel, indicated for ripening unfavorable cervices in pregnant women, should be available to consumers in February.
 Trofatter KF, Bowers D, Gall SA, et al: Preinduction cervical ripening with prostaglandin [E.sub.2] (Prepidil
Donette Bowers, Stanley A G, Allan P K, 1985, Preindcution cervical ripening with PGE2 (Prepidil
) gel, American Journal of Obstetrics and Gynecology, 1985: 153: 268-271.
Its advantages over prostaglandin E2/dinoprostone (Prepidil
gel[R] or Prandin[R]) are cost (R4.05/200 [micro]g tablet v.
Labour induction with intravaginal misoprostol versus intracervical prostaglandin E2 gel (Prepidil
gel): randomized comparison.